Abstract

Aim: The aim of the study was to investigate the risk of stroke in patients with cerebral palsy (CP), based on nationwide data in Taiwan. Method: This prospective cohort study was comprised of patients recorded on the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005) who had a diagnosis of CP (n=1975) in records between 1 January 2004 and 31 December 2007. A comparison group (1:5) drawn from the same database was matched for age and sex (n=9875). Each patient was tracked by data until the development of stroke or the end of 2008. Cox proportional-hazards regression analysis was used to evaluate the hazard ratios after adjusting for potential confounding factors. Results: Patients with CP were more likely to suffer stroke than the comparison population, after adjusting for potential confounding factors (adjusted hazard ratio: 2.17; 95% confidence interval [CI]: 1.74–2.69). The hazard ratio of stroke was 4.78 (95% CI: 3.18–7.17) and 1.57 (95% CI: 1.20–2.05) for patients with CP aged 50 years and under, and over 50 years respectively. Interpretation: Cerebral palsy is a risk factor or marker for stroke that is independent of traditional stroke risk factors. Further research in this area is warranted.
Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalDevelopmental Medicine and Child Neurology
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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Cerebral Palsy
Cohort Studies
Stroke
Population
Confidence Intervals
Taiwan
Databases
Health Insurance
Regression Analysis
Prospective Studies
Research

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Risk of stroke among patients with cerebral palsy : a population-based cohort study. / Wu, Chin Wen; Huang, Shih-Wei; Lin, Jia-Wei; Liou, Tsan-Hon; Chou, Lin Chuan; Lin, Hui Wen.

In: Developmental Medicine and Child Neurology, Vol. 59, No. 1, 01.01.2017, p. 52-56.

Research output: Contribution to journalArticle

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abstract = "Aim: The aim of the study was to investigate the risk of stroke in patients with cerebral palsy (CP), based on nationwide data in Taiwan. Method: This prospective cohort study was comprised of patients recorded on the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005) who had a diagnosis of CP (n=1975) in records between 1 January 2004 and 31 December 2007. A comparison group (1:5) drawn from the same database was matched for age and sex (n=9875). Each patient was tracked by data until the development of stroke or the end of 2008. Cox proportional-hazards regression analysis was used to evaluate the hazard ratios after adjusting for potential confounding factors. Results: Patients with CP were more likely to suffer stroke than the comparison population, after adjusting for potential confounding factors (adjusted hazard ratio: 2.17; 95{\%} confidence interval [CI]: 1.74–2.69). The hazard ratio of stroke was 4.78 (95{\%} CI: 3.18–7.17) and 1.57 (95{\%} CI: 1.20–2.05) for patients with CP aged 50 years and under, and over 50 years respectively. Interpretation: Cerebral palsy is a risk factor or marker for stroke that is independent of traditional stroke risk factors. Further research in this area is warranted.",
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