Risk of retinal diseases in patients with psoriasis: A population-based cohort study in Taiwan

Ying Xiu Dai, Ying Hsuan Tai, Din Dar Lee, Yun Ting Chang, Tzeng Ji Chen, Mu Hong Chen

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Psoriasis has been associated with the risk of several ocular complications; however, its relationship with retinal diseases remains unknown. This study aimed to investigate the risk of developing retinal diseases in patients with psoriasis. Study participants were recruited from the National Health Insurance Research Database in Taiwan. A total of 11 729 psoriasis patients and 117 290 matched controls were included, showing an incidence rate of 121.15 and 28.34 cases of retinal diseases per 100 000 person-years, respectively. Compared with controls, patients with psoriasis had an adjusted hazard ratio (aHR) of 3.40 (95% confidence interval [CI], 2.63–4.39) for retinal diseases after adjustment for potential confounders. Regarding the individual retinal disease, psoriasis patients had a significantly higher risk of developing retinal detachment (aHR, 5.07; 95% CI, 2.92–8.79), retinal vascular occlusion (aHR, 3.75; 95% CI 2.42–5.82), and retinopathy (aHR, 2.84; 95% CI, 1.99–4.05) than controls. In conclusion, patients with psoriasis had a significantly higher risk of retinal diseases than controls. Further studies are necessary to investigate the pathophysiology underlying the relationship between psoriasis and retinal diseases.

Original languageEnglish
Pages (from-to)1550-1556
Number of pages7
JournalJournal of Dermatology
Volume48
Issue number10
DOIs
Publication statusPublished - Oct 2021

Keywords

  • psoriasis
  • retinal detachment
  • retinal diseases
  • retinal vascular occlusion
  • retinopathy

ASJC Scopus subject areas

  • Dermatology

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