Risk of nonpsychotic mental disorders development in antiviral-treated mentally healthy chronic hepatitis C patients: A population-based study

Shu Chuan Chang, Chin Tun Hung, Shu Fen Li, Horng Mo Lee, Yueh Chin Chung, Lee Wen Pai, Sheng Shun Yang

Research output: Contribution to journalArticle

2 Citations (Scopus)


Background/Purpose: Interferon (IFN) is able to induce significant psychiatric side effects in chronic hepatitis C (CHC) patients, whereas the risk of nonpsychotic mental disorder (NPMD) development in antiviral-treated mentally healthy CHC patients remains obscure. We used a population-based study to assess the risk of NPMD development in patients who had undergone antiviral treatment compared with untreated chronic hepatitis C virus (HCV)-infected and nonalcoholic fatty liver disease (NAFLD) patients. Methods: Data were retrieved from Taiwan's National Health Insurance Research Database cohort consisting of 1 million individuals for a longitudinal analysis. A total of 313 mentally healthy CHC patients who received IFN-based antiviral therapy were recruited and compared with those without antiviral therapy and NAFLD patients. The Chi-square test was used to obtain the hazard ratio and 95% confidence interval. Results: Among the 313 CHC patients receiving pegylated interferon/ribavirin therapy, 62 patients (19.8%) were associated with NPMD. In the comparison cohort, composed of 313 age- and sex-matched CHC patients not receiving antiviral therapy, 70 patients (22.4%) were associated with NPMD. The Chi-square analysis revealed that antiviral therapy was not significantly associated with NPMD. The diagnosis of HCV-infected hepatitis was independently associated with NPMD when compared with NAFLD. The hazard ratio was 1.67 (95% confidence interval, 1.11-2.52; p = 0.018). Furthermore, generalized anxiety disorder was specifically higher in HCV-infected patients than those with NAFLD. Conclusion: Patients with HCV infection are at high risk of developing NPMD with or without IFN-based therapy.

Original languageEnglish
Pages (from-to)829-834
Number of pages6
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Issue number9
Publication statusPublished - Sep 1 2015
Externally publishedYes



  • Antiviral therapy
  • Chronic hepatitis C
  • Nonalcoholic fatty liver disease
  • Nonpsychotic mental disorders
  • Population-based study

ASJC Scopus subject areas

  • Medicine(all)

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