Abstract

Background: There is evidence that chronic inflammation may promote atherosclerotic disease. The purpose of this study was to test the hypothesis that pelvic inflammatory disease (PID) is a risk marker for myocardial infarction (MI). Method: Using the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005), this cohort study comprised patients with a recorded diagnosis of PID (N = 68,668) between January 1, 2004 and December 31, 2005, with age-matched controls (1:2) (N = 136,906). Each patient was followed-up using entry data until the end of 2006. Cox proportional hazard regressions were used to evaluate the up to 3-year MI-free survival rates, after adjusting for known confounding factors. Results: We found that patients with PID were more likely to have MI than the control population after adjusting for potential confounders [adjusted hazard ratio (HR), 1.86, 95% confidence interval (CI), 1.23-2.81]. When stratified by patient's age, the adjusted HR for MI was 2.09 (95% CI, 1.24-3.52) for patients with PID aged over 55 years. However, the adjusted HR for MI occurring was not significant for patients with PID aged ≤ 55 years. Conclusions: PID is a risk marker for MI that is independent of traditional MI risk factors. Further research in this important area of public health is warranted.

Original languageEnglish
Pages (from-to)416-420
Number of pages5
JournalInternational Journal of Cardiology
Volume167
Issue number2
DOIs
Publication statusPublished - Jul 31 2013

Fingerprint

Pelvic Inflammatory Disease
Myocardial Infarction
Confidence Intervals
Health Insurance
Taiwan
Cohort Studies
Survival Rate
Public Health
Databases
Inflammation
Research
Population

Keywords

  • Epidemiology
  • Incidence
  • MI
  • PID
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Risk of myocardial infarction in women with pelvic inflammatory disease. / Liou, Tsan Hon; Wu, Chin Wen; Hao, Wen Rui; Hsu, Ming I.; Liu, Ju Chi; Lin, Hui Wen.

In: International Journal of Cardiology, Vol. 167, No. 2, 31.07.2013, p. 416-420.

Research output: Contribution to journalArticle

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abstract = "Background: There is evidence that chronic inflammation may promote atherosclerotic disease. The purpose of this study was to test the hypothesis that pelvic inflammatory disease (PID) is a risk marker for myocardial infarction (MI). Method: Using the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005), this cohort study comprised patients with a recorded diagnosis of PID (N = 68,668) between January 1, 2004 and December 31, 2005, with age-matched controls (1:2) (N = 136,906). Each patient was followed-up using entry data until the end of 2006. Cox proportional hazard regressions were used to evaluate the up to 3-year MI-free survival rates, after adjusting for known confounding factors. Results: We found that patients with PID were more likely to have MI than the control population after adjusting for potential confounders [adjusted hazard ratio (HR), 1.86, 95{\%} confidence interval (CI), 1.23-2.81]. When stratified by patient's age, the adjusted HR for MI was 2.09 (95{\%} CI, 1.24-3.52) for patients with PID aged over 55 years. However, the adjusted HR for MI occurring was not significant for patients with PID aged ≤ 55 years. Conclusions: PID is a risk marker for MI that is independent of traditional MI risk factors. Further research in this important area of public health is warranted.",
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AU - Liu, Ju Chi

AU - Lin, Hui Wen

PY - 2013/7/31

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