Risk of ischemic stroke in primary aldosteronism patients

Chih Chin Kao, Che Hsiung Wu, Yen Hung Lin, Chin Chen Chang, Hsi Hsien Chen, Mai Szu Wu, Vin Cent Wu, Kwan Dun Wu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: High aldosterone concentrations are associated with the risk of stroke that is independent of blood pressure levels. We investigated the risk of ischemic stroke in primary aldosteronism (PA) patients. Methods: This retrospective case-control study was based on the Taiwan Primary Aldosteronism Investigation (TAIPAI) database from 2004 to 2010. The study group comprised the patients who developed ischemic stroke after the diagnosis of PA. The PA patients who did not develop stroke were matched according to age and sex as the control group. A multivariate logistic regression model was performed to determine the risk factors of ischemic stroke. Results: Of 339 patients diagnosed with PA, 22 patients (6.5%) developed de novo ischemic stroke. The PA patients with stroke suffered from a longer hypertensive period (11.0. ±. 6.5 vs 7.8. ±. 8.3, P=.007) and a higher prevalence of proteinuria than those who did not develop stroke (40.9% vs 12.9%, P=.002). A multivariate logistic regression model showed that PA patients with proteinuria (HR 3.58, P=.02), preexisting coronary artery disease (HR 11.12, P

Original languageEnglish
Pages (from-to)86-89
Number of pages4
JournalClinica Chimica Acta
Volume438
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Hyperaldosteronism
Stroke
Logistics
Logistic Models
Blood pressure
Aldosterone
Proteinuria
Taiwan
Case-Control Studies
Coronary Artery Disease
Databases
Blood Pressure
Control Groups

Keywords

  • Ischemic stroke
  • Primary aldosteronism
  • Proteinuria

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Medicine(all)

Cite this

Risk of ischemic stroke in primary aldosteronism patients. / Kao, Chih Chin; Wu, Che Hsiung; Lin, Yen Hung; Chang, Chin Chen; Chen, Hsi Hsien; Wu, Mai Szu; Wu, Vin Cent; Wu, Kwan Dun.

In: Clinica Chimica Acta, Vol. 438, 01.01.2015, p. 86-89.

Research output: Contribution to journalArticle

Kao, Chih Chin ; Wu, Che Hsiung ; Lin, Yen Hung ; Chang, Chin Chen ; Chen, Hsi Hsien ; Wu, Mai Szu ; Wu, Vin Cent ; Wu, Kwan Dun. / Risk of ischemic stroke in primary aldosteronism patients. In: Clinica Chimica Acta. 2015 ; Vol. 438. pp. 86-89.
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