Risk of head and neck cancer in patients with diabetes mellitus

A retrospective cohort study in Taiwan

Kuo Shu Tseng, Charlene Lin, Yong-Song Lin, Shih Feng Weng

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

IMPORTANCE: An increasing body of evidence suggests that certain types of cancers are more common in people with diabetes mellitus (DM). However, the risk of head and neck cancer (HNC) in patients with DM has seldom been explored. OBJECTIVE: To examine the risk of HNC in patients with DM. DESIGN, SETTING, AND PARTICIPANTS: In this retrospective cohort study using Taiwan's Longitudinal Health Insurance Research Database, we compared 89 089 patients newly diagnosed as having DMand controls without DM-related medical claims matched for comorbidities (obesity, coronary artery disease, hyperlipidemia, and hypertension), sex, and age. Patients were assessed from the index date until the end of follow-up on December 31, 2011, or until the patient was censored because of death. MAIN OUTCOMES AND MEASURES: The incidence of HNC at the end of 2011. RESULTS: The incidence of HNC was 1.47 times higher in patients newly diagnosed as having DM than was the risk of a first malignant tumor in the control group (adjusted hazard ratio [AHR], 1.48; 95%CI, 1.31-1.67). The risks of oral cancer (AHR, 1.74; 95%CI, 1.47-2.06), oropharyngeal cancer (AHR, 1.53; 95%CI, 1.01-2.31), and nasopharyngeal carcinoma (AHR, 1.40; 95%CI, 1.03-1.89) were significantly higher in patients with DM than in controls. CONCLUSIONS AND RELEVANCE: Diabetes is associated with an increased risk of developing HNC. The risks of developing oral cavity cancer, oropharyngeal cancer, and nasopharyngeal carcinoma were significantly higher in patients with DM.

Original languageEnglish
Pages (from-to)746-753
Number of pages8
JournalJAMA Otolaryngology - Head and Neck Surgery
Volume140
Issue number8
DOIs
Publication statusPublished - 2014

Fingerprint

Head and Neck Neoplasms
Taiwan
Diabetes Mellitus
Cohort Studies
Retrospective Studies
Oropharyngeal Neoplasms
Mouth Neoplasms
Incidence
Health Insurance
Hyperlipidemias
Mouth
Comorbidity
Coronary Artery Disease
Neoplasms
Obesity
Databases
Hypertension
Control Groups
Research

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery

Cite this

Risk of head and neck cancer in patients with diabetes mellitus : A retrospective cohort study in Taiwan. / Tseng, Kuo Shu; Lin, Charlene; Lin, Yong-Song; Weng, Shih Feng.

In: JAMA Otolaryngology - Head and Neck Surgery, Vol. 140, No. 8, 2014, p. 746-753.

Research output: Contribution to journalArticle

Tseng, Kuo Shu ; Lin, Charlene ; Lin, Yong-Song ; Weng, Shih Feng. / Risk of head and neck cancer in patients with diabetes mellitus : A retrospective cohort study in Taiwan. In: JAMA Otolaryngology - Head and Neck Surgery. 2014 ; Vol. 140, No. 8. pp. 746-753.
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abstract = "IMPORTANCE: An increasing body of evidence suggests that certain types of cancers are more common in people with diabetes mellitus (DM). However, the risk of head and neck cancer (HNC) in patients with DM has seldom been explored. OBJECTIVE: To examine the risk of HNC in patients with DM. DESIGN, SETTING, AND PARTICIPANTS: In this retrospective cohort study using Taiwan's Longitudinal Health Insurance Research Database, we compared 89 089 patients newly diagnosed as having DMand controls without DM-related medical claims matched for comorbidities (obesity, coronary artery disease, hyperlipidemia, and hypertension), sex, and age. Patients were assessed from the index date until the end of follow-up on December 31, 2011, or until the patient was censored because of death. MAIN OUTCOMES AND MEASURES: The incidence of HNC at the end of 2011. RESULTS: The incidence of HNC was 1.47 times higher in patients newly diagnosed as having DM than was the risk of a first malignant tumor in the control group (adjusted hazard ratio [AHR], 1.48; 95{\%}CI, 1.31-1.67). The risks of oral cancer (AHR, 1.74; 95{\%}CI, 1.47-2.06), oropharyngeal cancer (AHR, 1.53; 95{\%}CI, 1.01-2.31), and nasopharyngeal carcinoma (AHR, 1.40; 95{\%}CI, 1.03-1.89) were significantly higher in patients with DM than in controls. CONCLUSIONS AND RELEVANCE: Diabetes is associated with an increased risk of developing HNC. The risks of developing oral cavity cancer, oropharyngeal cancer, and nasopharyngeal carcinoma were significantly higher in patients with DM.",
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