Risk of dementia in patients with non-haemorrhagic stroke receiving acupuncture treatment: a nationwide matched cohort study from Taiwan's National Health Insurance Research Database

Chun-Chuan Shih, Chun-Chieh Yeh, Chaur-Jong Hu, Hsin-Long Lane, Chin-Chuan Tsai, Ta-Liang Chen, Chien-Chang Liao

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the risk of dementia in patients with stroke who did and did not receive acupuncture treatment.

DESIGN: Retrospective cohort study.

SETTING: This study was based on Taiwan's National Health Insurance Research Database that included patients with stroke hospitalised between 1 January 2000 and 31 December 2004.

PARTICIPANTS: We identified 11 220 patients aged 50 years and older with newly diagnosed stroke hospitalisation.

PRIMARY AND SECONDARY OUTCOME MEASURES: We compared the incident dementia during the follow-up period until the end of 2009 in patients with stroke who did and did not receive acupuncture. The adjusted HRs and 95% CIs of dementia associated with acupuncture were calculated in multivariate Cox proportional hazard regressions.

RESULTS: Acupuncture treatment was associated with a decreased risk of dementia with multivariate adjustment (HR, 0.73; 95% CI 0.66 to 0.80), and the association was significant in both sexes and every age group, as well as in groups with ischaemic stroke, with fewer medical conditions and those hospitalised after stroke. Patients with stroke received acupuncture treatment, and conventional rehabilitation was associated with a significantly reduced risk of poststroke dementia (HR, 0.64; 95% CI 0.56 to 0.74).

CONCLUSIONS: This study raises the possibility that patients with non-haemorrhagic stroke who received acupuncture had a reduced risk of dementia. The results suggest the need for prospective sham-controlled and randomised trials to establish the efficacy of acupuncture in preventing dementia.

Original languageEnglish
Pages (from-to)e013638
JournalBMJ Open
Volume7
Issue number6
DOIs
Publication statusPublished - Jul 5 2017

Fingerprint

Acupuncture Therapy
National Health Programs
Taiwan
Dementia
Cohort Studies
Stroke
Databases
Acupuncture
Research
Social Adjustment
Hospitalization
Rehabilitation
Randomized Controlled Trials
Retrospective Studies
Age Groups
Outcome Assessment (Health Care)

Keywords

  • Journal Article

Cite this

Risk of dementia in patients with non-haemorrhagic stroke receiving acupuncture treatment : a nationwide matched cohort study from Taiwan's National Health Insurance Research Database. / Shih, Chun-Chuan; Yeh, Chun-Chieh; Hu, Chaur-Jong; Lane, Hsin-Long; Tsai, Chin-Chuan; Chen, Ta-Liang; Liao, Chien-Chang.

In: BMJ Open, Vol. 7, No. 6, 05.07.2017, p. e013638.

Research output: Contribution to journalArticle

@article{2797155311d9445599384f82ab174826,
title = "Risk of dementia in patients with non-haemorrhagic stroke receiving acupuncture treatment: a nationwide matched cohort study from Taiwan's National Health Insurance Research Database",
abstract = "OBJECTIVE: To investigate the risk of dementia in patients with stroke who did and did not receive acupuncture treatment.DESIGN: Retrospective cohort study.SETTING: This study was based on Taiwan's National Health Insurance Research Database that included patients with stroke hospitalised between 1 January 2000 and 31 December 2004.PARTICIPANTS: We identified 11 220 patients aged 50 years and older with newly diagnosed stroke hospitalisation.PRIMARY AND SECONDARY OUTCOME MEASURES: We compared the incident dementia during the follow-up period until the end of 2009 in patients with stroke who did and did not receive acupuncture. The adjusted HRs and 95{\%} CIs of dementia associated with acupuncture were calculated in multivariate Cox proportional hazard regressions.RESULTS: Acupuncture treatment was associated with a decreased risk of dementia with multivariate adjustment (HR, 0.73; 95{\%} CI 0.66 to 0.80), and the association was significant in both sexes and every age group, as well as in groups with ischaemic stroke, with fewer medical conditions and those hospitalised after stroke. Patients with stroke received acupuncture treatment, and conventional rehabilitation was associated with a significantly reduced risk of poststroke dementia (HR, 0.64; 95{\%} CI 0.56 to 0.74).CONCLUSIONS: This study raises the possibility that patients with non-haemorrhagic stroke who received acupuncture had a reduced risk of dementia. The results suggest the need for prospective sham-controlled and randomised trials to establish the efficacy of acupuncture in preventing dementia.",
keywords = "Journal Article",
author = "Chun-Chuan Shih and Chun-Chieh Yeh and Chaur-Jong Hu and Hsin-Long Lane and Chin-Chuan Tsai and Ta-Liang Chen and Chien-Chang Liao",
note = "{\circledC} Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.",
year = "2017",
month = "7",
day = "5",
doi = "10.1136/bmjopen-2016-013638",
language = "English",
volume = "7",
pages = "e013638",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "6",

}

TY - JOUR

T1 - Risk of dementia in patients with non-haemorrhagic stroke receiving acupuncture treatment

T2 - a nationwide matched cohort study from Taiwan's National Health Insurance Research Database

AU - Shih, Chun-Chuan

AU - Yeh, Chun-Chieh

AU - Hu, Chaur-Jong

AU - Lane, Hsin-Long

AU - Tsai, Chin-Chuan

AU - Chen, Ta-Liang

AU - Liao, Chien-Chang

N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

PY - 2017/7/5

Y1 - 2017/7/5

N2 - OBJECTIVE: To investigate the risk of dementia in patients with stroke who did and did not receive acupuncture treatment.DESIGN: Retrospective cohort study.SETTING: This study was based on Taiwan's National Health Insurance Research Database that included patients with stroke hospitalised between 1 January 2000 and 31 December 2004.PARTICIPANTS: We identified 11 220 patients aged 50 years and older with newly diagnosed stroke hospitalisation.PRIMARY AND SECONDARY OUTCOME MEASURES: We compared the incident dementia during the follow-up period until the end of 2009 in patients with stroke who did and did not receive acupuncture. The adjusted HRs and 95% CIs of dementia associated with acupuncture were calculated in multivariate Cox proportional hazard regressions.RESULTS: Acupuncture treatment was associated with a decreased risk of dementia with multivariate adjustment (HR, 0.73; 95% CI 0.66 to 0.80), and the association was significant in both sexes and every age group, as well as in groups with ischaemic stroke, with fewer medical conditions and those hospitalised after stroke. Patients with stroke received acupuncture treatment, and conventional rehabilitation was associated with a significantly reduced risk of poststroke dementia (HR, 0.64; 95% CI 0.56 to 0.74).CONCLUSIONS: This study raises the possibility that patients with non-haemorrhagic stroke who received acupuncture had a reduced risk of dementia. The results suggest the need for prospective sham-controlled and randomised trials to establish the efficacy of acupuncture in preventing dementia.

AB - OBJECTIVE: To investigate the risk of dementia in patients with stroke who did and did not receive acupuncture treatment.DESIGN: Retrospective cohort study.SETTING: This study was based on Taiwan's National Health Insurance Research Database that included patients with stroke hospitalised between 1 January 2000 and 31 December 2004.PARTICIPANTS: We identified 11 220 patients aged 50 years and older with newly diagnosed stroke hospitalisation.PRIMARY AND SECONDARY OUTCOME MEASURES: We compared the incident dementia during the follow-up period until the end of 2009 in patients with stroke who did and did not receive acupuncture. The adjusted HRs and 95% CIs of dementia associated with acupuncture were calculated in multivariate Cox proportional hazard regressions.RESULTS: Acupuncture treatment was associated with a decreased risk of dementia with multivariate adjustment (HR, 0.73; 95% CI 0.66 to 0.80), and the association was significant in both sexes and every age group, as well as in groups with ischaemic stroke, with fewer medical conditions and those hospitalised after stroke. Patients with stroke received acupuncture treatment, and conventional rehabilitation was associated with a significantly reduced risk of poststroke dementia (HR, 0.64; 95% CI 0.56 to 0.74).CONCLUSIONS: This study raises the possibility that patients with non-haemorrhagic stroke who received acupuncture had a reduced risk of dementia. The results suggest the need for prospective sham-controlled and randomised trials to establish the efficacy of acupuncture in preventing dementia.

KW - Journal Article

U2 - 10.1136/bmjopen-2016-013638

DO - 10.1136/bmjopen-2016-013638

M3 - Article

C2 - 28679673

VL - 7

SP - e013638

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 6

ER -