Risk of cardiovascular diseases and stroke events in methamphetamine users: A 10-year follow-up study

Ming Chyi Huang, Shu Yu Yang, Shih Ku Lin, Kuan Yu Chen, Ying Yeh Chen, Chian Jue Kuo, Yen-Ni Hung

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: Long-term follow-up data regarding the association between methamphetamine use and cardiovascular and cerebrovascular complications are scarce. We investigated the risk of complications in methamphetamine users over a decade. Methods: A total of 1,315 inpatients treated for methamphetamine use were recruited from the Psychiatric Inpatient Medical Claims database in Taiwan between January 1, 1997, and December 31, 2000, and matched with a population proxy comparison group at a ratio of 1:4 through propensity score matching. All patients were monitored for any incident complication until December 31, 2010. Cox proportional hazards model was used to estimate the risk of ICD-9-CM cardiovascular diseases and stroke events. Results: The patients were mostly male, and approximately half were younger than 30 years. The methamphetamine cohort had higher incidences of cardiovascular diseases and stroke events than the comparison cohort (87.5/10,000 vs 55.3/10,000 person-years, P < .001) and was significantly associated with an increased risk of the complications (hazard ratio [HR] = 1.55, P < .001), particularly arrhythmia (HR = 1.92, P = .014) and hemorrhagic stroke (HR = 2.09, P = .001). The risk of cardiovascular sequelae was more significant in younger patients (<30 y) (HR = 2.22, P = .001), whereas the risk of stroke events was higher among the older patients (≥ 30 y) (HR = 1.86, P = .001). Conclusions: Methamphetamine use is significantly associated with a risk of subsequent cardiovascular and cerebrovascular complications. Age appears to be an effect modifier for the risk estimation.

Original languageEnglish
Pages (from-to)1396-1403
Number of pages8
JournalJournal of Clinical Psychiatry
Volume77
Issue number10
DOIs
Publication statusPublished - Oct 1 2016

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Methamphetamine
antineoplaston A10
Cardiovascular Diseases
Myocardial Infarction
Inpatients
Stroke
Propensity Score
Proxy
International Classification of Diseases
Taiwan
Proportional Hazards Models
Psychiatry
Cardiac Arrhythmias
Databases
Incidence
Population

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Huang, M. C., Yang, S. Y., Lin, S. K., Chen, K. Y., Chen, Y. Y., Kuo, C. J., & Hung, Y-N. (2016). Risk of cardiovascular diseases and stroke events in methamphetamine users: A 10-year follow-up study. Journal of Clinical Psychiatry, 77(10), 1396-1403. https://doi.org/10.4088/JCP.15m09872

Risk of cardiovascular diseases and stroke events in methamphetamine users : A 10-year follow-up study. / Huang, Ming Chyi; Yang, Shu Yu; Lin, Shih Ku; Chen, Kuan Yu; Chen, Ying Yeh; Kuo, Chian Jue; Hung, Yen-Ni.

In: Journal of Clinical Psychiatry, Vol. 77, No. 10, 01.10.2016, p. 1396-1403.

Research output: Contribution to journalArticle

Huang, MC, Yang, SY, Lin, SK, Chen, KY, Chen, YY, Kuo, CJ & Hung, Y-N 2016, 'Risk of cardiovascular diseases and stroke events in methamphetamine users: A 10-year follow-up study', Journal of Clinical Psychiatry, vol. 77, no. 10, pp. 1396-1403. https://doi.org/10.4088/JCP.15m09872
Huang, Ming Chyi ; Yang, Shu Yu ; Lin, Shih Ku ; Chen, Kuan Yu ; Chen, Ying Yeh ; Kuo, Chian Jue ; Hung, Yen-Ni. / Risk of cardiovascular diseases and stroke events in methamphetamine users : A 10-year follow-up study. In: Journal of Clinical Psychiatry. 2016 ; Vol. 77, No. 10. pp. 1396-1403.
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