Abstract

The rates of Cesarean delivery (C-section) have risen to >30 % in numerous countries. Increased risk of autism has been shown in neonates delivered by C-section. This study examined the incidence of autism in neonates delivered vaginally, by C-section with regional anesthesia (RA), and by C-section with general anesthesia (GA) to evaluate the risk of autism associated with C-section and obstetric anesthesia. During a mean follow-up of 4.3 years, the incidence of autism was higher in neonates delivered by C-section with GA than in neonates delivered vaginally, with an adjusted risk of 1.52 (95 % confidence interval 1.18–1.94). However, the adjusted risk of autism in neonates delivered by C-section with RA and in neonates delivered vaginally was nonsignificantly different.

Original languageEnglish
Pages (from-to)932-942
Number of pages11
JournalJournal of Autism and Developmental Disorders
Volume45
Issue number4
DOIs
Publication statusPublished - 2015

Fingerprint

Autistic Disorder
General Anesthesia
Cohort Studies
Parturition
Conduction Anesthesia
Population
Obstetrical Anesthesia
Confidence Intervals
Incidence

Keywords

  • Autism
  • Cesarean delivery
  • Obstetric anesthesia
  • Population-based birth cohort

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Medicine(all)

Cite this

@article{7e7aa7960c074870af17bcfeda2ba203,
title = "Risk of Autism Associated With General Anesthesia During Cesarean Delivery: A Population-Based Birth-Cohort Analysis",
abstract = "The rates of Cesarean delivery (C-section) have risen to >30 {\%} in numerous countries. Increased risk of autism has been shown in neonates delivered by C-section. This study examined the incidence of autism in neonates delivered vaginally, by C-section with regional anesthesia (RA), and by C-section with general anesthesia (GA) to evaluate the risk of autism associated with C-section and obstetric anesthesia. During a mean follow-up of 4.3 years, the incidence of autism was higher in neonates delivered by C-section with GA than in neonates delivered vaginally, with an adjusted risk of 1.52 (95 {\%} confidence interval 1.18–1.94). However, the adjusted risk of autism in neonates delivered by C-section with RA and in neonates delivered vaginally was nonsignificantly different.",
keywords = "Autism, Cesarean delivery, Obstetric anesthesia, Population-based birth cohort",
author = "Chien, {Li Nien} and Lin, {Hsiu Chen} and Shao, {Yu Hsuan Joni} and Chiou, {Shu Ti} and Chiou, {Hung Yi}",
year = "2015",
doi = "10.1007/s10803-014-2247-y",
language = "English",
volume = "45",
pages = "932--942",
journal = "Journal of Autism and Developmental Disorders",
issn = "0162-3257",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Risk of Autism Associated With General Anesthesia During Cesarean Delivery

T2 - A Population-Based Birth-Cohort Analysis

AU - Chien, Li Nien

AU - Lin, Hsiu Chen

AU - Shao, Yu Hsuan Joni

AU - Chiou, Shu Ti

AU - Chiou, Hung Yi

PY - 2015

Y1 - 2015

N2 - The rates of Cesarean delivery (C-section) have risen to >30 % in numerous countries. Increased risk of autism has been shown in neonates delivered by C-section. This study examined the incidence of autism in neonates delivered vaginally, by C-section with regional anesthesia (RA), and by C-section with general anesthesia (GA) to evaluate the risk of autism associated with C-section and obstetric anesthesia. During a mean follow-up of 4.3 years, the incidence of autism was higher in neonates delivered by C-section with GA than in neonates delivered vaginally, with an adjusted risk of 1.52 (95 % confidence interval 1.18–1.94). However, the adjusted risk of autism in neonates delivered by C-section with RA and in neonates delivered vaginally was nonsignificantly different.

AB - The rates of Cesarean delivery (C-section) have risen to >30 % in numerous countries. Increased risk of autism has been shown in neonates delivered by C-section. This study examined the incidence of autism in neonates delivered vaginally, by C-section with regional anesthesia (RA), and by C-section with general anesthesia (GA) to evaluate the risk of autism associated with C-section and obstetric anesthesia. During a mean follow-up of 4.3 years, the incidence of autism was higher in neonates delivered by C-section with GA than in neonates delivered vaginally, with an adjusted risk of 1.52 (95 % confidence interval 1.18–1.94). However, the adjusted risk of autism in neonates delivered by C-section with RA and in neonates delivered vaginally was nonsignificantly different.

KW - Autism

KW - Cesarean delivery

KW - Obstetric anesthesia

KW - Population-based birth cohort

UR - http://www.scopus.com/inward/record.url?scp=84925492013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925492013&partnerID=8YFLogxK

U2 - 10.1007/s10803-014-2247-y

DO - 10.1007/s10803-014-2247-y

M3 - Article

VL - 45

SP - 932

EP - 942

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

SN - 0162-3257

IS - 4

ER -