Risk group characteristics and viral transmission clusters in South-East Asian patients infected with human immunodeficiency virus-1 (HIV-1) circulating recombinant form (CRF) 01-AE and subtype B

Rebecca A. Oyomopito, Yen Ju Chen, Somnuek Sungkanuparph, Rami Kantor, Tuti Merati, Wing Cheong Yam, Thira Sirisanthana, Patrick C.K. Li, Pacharee Kantipong, Praphan Phanuphak, Chris K.C. Lee, Adeeba Kamarulzaman, Rossana Ditangco, Szu Wei Huang, Annette H. Sohn, Matthew Law, Yi Ming A. Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV)-1 epidemics in Asian countries are driven by varying exposures. The epidemiology of the regional pandemic has been changing with the spread of HIV-1 to lower-risk populations through sexual transmission. Common HIV-1 genotypes include subtype B and circulating recombinant form (CRF) 01-AE. Our objective was to use HIV-1 genotypic data to better quantify local epidemics. TASER-M is a multicenter prospective cohort of HIV-infected patients. Associations between HIV exposure, patient sex, country of sample origin and HIV-1 genotype were evaluated by multivariate logistic regression. Phylogenetic methods were used on genotypic data to investigate transmission relationships. A total of 1086 patients from Thailand, Hong Kong, Malaysia and the Philippines were included in analyses. Proportions of male patients within countries varied (Thailand: 55.6%, Hong Kong: 86.1%, Malaysia: 81.4%, Philippines: 93.8%; p < 0.001) as did HIV exposures (heterosexual contact: Thailand: 85.7%, Hong Kong, 46.2%, Malaysia: 47.8%, Philippines: 25.0%; p < 0.001). After adjustment, we found increased subtype B infection among men who have sex with men, relative to heterosexual-reported exposures (odds ratio = 2.4, p < 0.001). We further describe four transmission clusters of eight to 15 treatment naïve, predominantly symptomatic patients (two each for subtype B and CRF01-AE). Risk-group subpopulations differed with respect to the infecting HIV-1 genotype. Homosexual exposure patients had higher odds of being infected with subtype B. Where HIV-1 genotypes circulate within countries or patient risk-groups, local monitoring of genotype-specific transmissions may play a role in focusing public health prevention strategies. Phylogenetic evaluations provide complementary information for surveillance and monitoring of viruses with high mutation rates such as HIV-1 and Ebola.

Original languageEnglish
Pages (from-to)445-453
Number of pages9
JournalKaohsiung Journal of Medical Sciences
Volume31
Issue number9
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

Fingerprint

HIV-1
Genotype
Philippines
Malaysia
Hong Kong
Thailand
Heterosexuality
HIV
Social Adjustment
Pandemics
Mutation Rate
Epidemiology
Public Health
Logistic Models
Odds Ratio
Viruses
Infection
Population

Keywords

  • Asia
  • CRF01-AE
  • HIV exposure
  • Subtype B

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Risk group characteristics and viral transmission clusters in South-East Asian patients infected with human immunodeficiency virus-1 (HIV-1) circulating recombinant form (CRF) 01-AE and subtype B. / Oyomopito, Rebecca A.; Chen, Yen Ju; Sungkanuparph, Somnuek; Kantor, Rami; Merati, Tuti; Yam, Wing Cheong; Sirisanthana, Thira; Li, Patrick C.K.; Kantipong, Pacharee; Phanuphak, Praphan; Lee, Chris K.C.; Kamarulzaman, Adeeba; Ditangco, Rossana; Huang, Szu Wei; Sohn, Annette H.; Law, Matthew; Chen, Yi Ming A.

In: Kaohsiung Journal of Medical Sciences, Vol. 31, No. 9, 01.01.2015, p. 445-453.

Research output: Contribution to journalArticle

Oyomopito, RA, Chen, YJ, Sungkanuparph, S, Kantor, R, Merati, T, Yam, WC, Sirisanthana, T, Li, PCK, Kantipong, P, Phanuphak, P, Lee, CKC, Kamarulzaman, A, Ditangco, R, Huang, SW, Sohn, AH, Law, M & Chen, YMA 2015, 'Risk group characteristics and viral transmission clusters in South-East Asian patients infected with human immunodeficiency virus-1 (HIV-1) circulating recombinant form (CRF) 01-AE and subtype B', Kaohsiung Journal of Medical Sciences, vol. 31, no. 9, pp. 445-453. https://doi.org/10.1016/j.kjms.2015.07.002
Oyomopito, Rebecca A. ; Chen, Yen Ju ; Sungkanuparph, Somnuek ; Kantor, Rami ; Merati, Tuti ; Yam, Wing Cheong ; Sirisanthana, Thira ; Li, Patrick C.K. ; Kantipong, Pacharee ; Phanuphak, Praphan ; Lee, Chris K.C. ; Kamarulzaman, Adeeba ; Ditangco, Rossana ; Huang, Szu Wei ; Sohn, Annette H. ; Law, Matthew ; Chen, Yi Ming A. / Risk group characteristics and viral transmission clusters in South-East Asian patients infected with human immunodeficiency virus-1 (HIV-1) circulating recombinant form (CRF) 01-AE and subtype B. In: Kaohsiung Journal of Medical Sciences. 2015 ; Vol. 31, No. 9. pp. 445-453.
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abstract = "Human immunodeficiency virus (HIV)-1 epidemics in Asian countries are driven by varying exposures. The epidemiology of the regional pandemic has been changing with the spread of HIV-1 to lower-risk populations through sexual transmission. Common HIV-1 genotypes include subtype B and circulating recombinant form (CRF) 01-AE. Our objective was to use HIV-1 genotypic data to better quantify local epidemics. TASER-M is a multicenter prospective cohort of HIV-infected patients. Associations between HIV exposure, patient sex, country of sample origin and HIV-1 genotype were evaluated by multivariate logistic regression. Phylogenetic methods were used on genotypic data to investigate transmission relationships. A total of 1086 patients from Thailand, Hong Kong, Malaysia and the Philippines were included in analyses. Proportions of male patients within countries varied (Thailand: 55.6{\%}, Hong Kong: 86.1{\%}, Malaysia: 81.4{\%}, Philippines: 93.8{\%}; p < 0.001) as did HIV exposures (heterosexual contact: Thailand: 85.7{\%}, Hong Kong, 46.2{\%}, Malaysia: 47.8{\%}, Philippines: 25.0{\%}; p < 0.001). After adjustment, we found increased subtype B infection among men who have sex with men, relative to heterosexual-reported exposures (odds ratio = 2.4, p < 0.001). We further describe four transmission clusters of eight to 15 treatment na{\"i}ve, predominantly symptomatic patients (two each for subtype B and CRF01-AE). Risk-group subpopulations differed with respect to the infecting HIV-1 genotype. Homosexual exposure patients had higher odds of being infected with subtype B. Where HIV-1 genotypes circulate within countries or patient risk-groups, local monitoring of genotype-specific transmissions may play a role in focusing public health prevention strategies. Phylogenetic evaluations provide complementary information for surveillance and monitoring of viruses with high mutation rates such as HIV-1 and Ebola.",
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