Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer

William Wang Yu Su, Shu Lin Chuang, Amy Ming Fang Yen, Sam Li Sheng Chen, Jean Ching Yuan Fann, Sherry Yueh Hsia Chiu, Han Mo Chiu, Chiu Wen Su, Chen Yang Hsu, Mu Kuan Chen, Hsiu Hsi Chen, Cheng Ping Wang, Yi Chia Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC-HE) among individuals with an initial oral/oropharyngeal cancer. Materials and Methods: Mass screening data from Taiwan (2004–2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC-HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI). Results: One hundred and fifty-eight out of 4,494 subjects with oral cancer developed SPC-HE (incidence rate: 6.47 per 1,000 person-years). Relative to patients with primary cancers in the lip, the risk of an SPC-HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95% CI: 4.72–84.55), floor of mouth (aRR: 12.13, 95% CI: 2.67–55.15), and hard palate (aRR: 7.31, 95% CI: 1.65–32.37), but not in patients with cancers in tongue (aRR: 3.67, 95% CI: 0.89–15.17) or gum (aRR: 3.99, 95% CI: 0.92–17.35). Regression analyses also showed the risk of an SPC-HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95% CI: 1.10–2.48). Conclusions: Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC-HE.

Original languageEnglish
Pages (from-to)1067-1075
Number of pages9
JournalOral Diseases
Volume25
Issue number4
DOIs
Publication statusPublished - May 1 2019

Fingerprint

Hypopharyngeal Neoplasms
Second Primary Neoplasms
Mouth Neoplasms
Esophageal Neoplasms
Hypopharynx
Esophagus
Confidence Intervals
Oropharyngeal Neoplasms
Lip Neoplasms
Hard Palate
Mouth Floor
Tongue Neoplasms
Mass Screening
Gingiva
Taiwan
Tobacco Products

Keywords

  • cancer screening
  • esophageal cancer
  • hypopharyngeal cancer
  • oral/oropharyngeal cancer
  • second primary cancer

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer. / Su, William Wang Yu; Chuang, Shu Lin; Yen, Amy Ming Fang; Chen, Sam Li Sheng; Fann, Jean Ching Yuan; Chiu, Sherry Yueh Hsia; Chiu, Han Mo; Su, Chiu Wen; Hsu, Chen Yang; Chen, Mu Kuan; Chen, Hsiu Hsi; Wang, Cheng Ping; Lee, Yi Chia.

In: Oral Diseases, Vol. 25, No. 4, 01.05.2019, p. 1067-1075.

Research output: Contribution to journalArticle

Su, WWY, Chuang, SL, Yen, AMF, Chen, SLS, Fann, JCY, Chiu, SYH, Chiu, HM, Su, CW, Hsu, CY, Chen, MK, Chen, HH, Wang, CP & Lee, YC 2019, 'Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer', Oral Diseases, vol. 25, no. 4, pp. 1067-1075. https://doi.org/10.1111/odi.13080
Su, William Wang Yu ; Chuang, Shu Lin ; Yen, Amy Ming Fang ; Chen, Sam Li Sheng ; Fann, Jean Ching Yuan ; Chiu, Sherry Yueh Hsia ; Chiu, Han Mo ; Su, Chiu Wen ; Hsu, Chen Yang ; Chen, Mu Kuan ; Chen, Hsiu Hsi ; Wang, Cheng Ping ; Lee, Yi Chia. / Risk for a second primary hypopharyngeal and esophageal cancer after an initial primary oral cancer. In: Oral Diseases. 2019 ; Vol. 25, No. 4. pp. 1067-1075.
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abstract = "Objective: To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC-HE) among individuals with an initial oral/oropharyngeal cancer. Materials and Methods: Mass screening data from Taiwan (2004–2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC-HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95{\%} confidence interval (CI). Results: One hundred and fifty-eight out of 4,494 subjects with oral cancer developed SPC-HE (incidence rate: 6.47 per 1,000 person-years). Relative to patients with primary cancers in the lip, the risk of an SPC-HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95{\%} CI: 4.72–84.55), floor of mouth (aRR: 12.13, 95{\%} CI: 2.67–55.15), and hard palate (aRR: 7.31, 95{\%} CI: 1.65–32.37), but not in patients with cancers in tongue (aRR: 3.67, 95{\%} CI: 0.89–15.17) or gum (aRR: 3.99, 95{\%} CI: 0.92–17.35). Regression analyses also showed the risk of an SPC-HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95{\%} CI: 1.10–2.48). Conclusions: Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC-HE.",
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AU - Chuang, Shu Lin

AU - Yen, Amy Ming Fang

AU - Chen, Sam Li Sheng

AU - Fann, Jean Ching Yuan

AU - Chiu, Sherry Yueh Hsia

AU - Chiu, Han Mo

AU - Su, Chiu Wen

AU - Hsu, Chen Yang

AU - Chen, Mu Kuan

AU - Chen, Hsiu Hsi

AU - Wang, Cheng Ping

AU - Lee, Yi Chia

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N2 - Objective: To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC-HE) among individuals with an initial oral/oropharyngeal cancer. Materials and Methods: Mass screening data from Taiwan (2004–2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC-HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI). Results: One hundred and fifty-eight out of 4,494 subjects with oral cancer developed SPC-HE (incidence rate: 6.47 per 1,000 person-years). Relative to patients with primary cancers in the lip, the risk of an SPC-HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95% CI: 4.72–84.55), floor of mouth (aRR: 12.13, 95% CI: 2.67–55.15), and hard palate (aRR: 7.31, 95% CI: 1.65–32.37), but not in patients with cancers in tongue (aRR: 3.67, 95% CI: 0.89–15.17) or gum (aRR: 3.99, 95% CI: 0.92–17.35). Regression analyses also showed the risk of an SPC-HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95% CI: 1.10–2.48). Conclusions: Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC-HE.

AB - Objective: To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC-HE) among individuals with an initial oral/oropharyngeal cancer. Materials and Methods: Mass screening data from Taiwan (2004–2009) included individuals who were ≥18 years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC-HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI). Results: One hundred and fifty-eight out of 4,494 subjects with oral cancer developed SPC-HE (incidence rate: 6.47 per 1,000 person-years). Relative to patients with primary cancers in the lip, the risk of an SPC-HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95% CI: 4.72–84.55), floor of mouth (aRR: 12.13, 95% CI: 2.67–55.15), and hard palate (aRR: 7.31, 95% CI: 1.65–32.37), but not in patients with cancers in tongue (aRR: 3.67, 95% CI: 0.89–15.17) or gum (aRR: 3.99, 95% CI: 0.92–17.35). Regression analyses also showed the risk of an SPC-HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95% CI: 1.10–2.48). Conclusions: Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC-HE.

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KW - second primary cancer

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