Risk Factors of Post-Surgical Neuropathic Pain in Cesarean Section Patients: A Population-based Study

李裕祥, Nandini Meganathan, 高銘章, 黃思誠, 蔡佩珊, 黃俊仁

Research output: Contribution to journalArticle

Abstract

Background: We elucidated the incidence and the risk factors of post-surgical neuropathic pain (PSNP) in Cesarean section (CS) patients. Methods: Data from the Taiwan Longitudinal Health Insurance Database were analyzed. CS patients with a primary diagnosis of PSNP and had at least two ambulatory visits for PSNP treatments were identified as the PSNP subjects. CS patients without PSNP diagnosis were identified as the non-PSNP subjects. The PSNP and non-PSNP subjects were tracked from the surgery date until the end of 2008 or until loss of follow-up. Subjects with a previous history of PSNP before CS, age less than 16 or more than 50 years or missing data of anesthetic mode were excluded. Results: A total of 85 PSNP subjects and 11284 non-PSNP subjects were included. Multivariate logistic regression analyses revealed that diabetes mellitus was a risk factor of PNSP in CS patients [odds ratio (OR)=27, 95% confidence intervals (CI): 15.73 - 46.36; P<O.OOI]. The other risk factors of PSNP in CS patients included age ≧ 35 years (OR=3.25, 95% CI: 2.01. 5.28; P<0.001), hypertension (OR=2.48, 95% CI: 1.12 - 5.50; P=0.026), hyperlipidemia (OR=3.08, 95% CI: 1.29 - 7.39; P=0.012), chronic alcohol exposure (OR=9.61 , 95% CI: 1.53 - 60.27; P=0.016), smoking (OR=3.09, 95% CI: 1.54 - 6.21; P=0.001) and use of antidepressants (OR=7.40, 95% CI: 3.56 - 15.37; P<0.001). Conclusions: The incidence of PSNP in CS patients was 0.74% and the risk factors included DM, age ≧ 35 years, hypertension, hyperlipidemia, chronic alcohol exposure, smoking and use of antidepressants.
Original languageEnglish
Pages (from-to)61-69
Number of pages9
Journal疼痛醫學雜誌
Volume25
Issue number2
Publication statusPublished - 2015

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Neuralgia
Cesarean Section
Population
Odds Ratio
Confidence Intervals
Hyperlipidemias
Antidepressive Agents
Smoking
Alcohols
Hypertension
Incidence
Health Insurance
Taiwan
Anesthetics
Diabetes Mellitus
Logistic Models
Regression Analysis
Databases

Keywords

  • 剖腹產
  • 術後神經性疼痛
  • 風險因子
  • 族群基礎之研究
  • Cesarean section
  • post-surgical neuropathic pam
  • risk factor
  • population-based study

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Risk Factors of Post-Surgical Neuropathic Pain in Cesarean Section Patients : A Population-based Study. / 李裕祥; Meganathan, Nandini; 高銘章; 黃思誠; 蔡佩珊; 黃俊仁.

In: 疼痛醫學雜誌, Vol. 25, No. 2, 2015, p. 61-69.

Research output: Contribution to journalArticle

李裕祥 ; Meganathan, Nandini ; 高銘章 ; 黃思誠 ; 蔡佩珊 ; 黃俊仁. / Risk Factors of Post-Surgical Neuropathic Pain in Cesarean Section Patients : A Population-based Study. In: 疼痛醫學雜誌. 2015 ; Vol. 25, No. 2. pp. 61-69.
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abstract = "Background: We elucidated the incidence and the risk factors of post-surgical neuropathic pain (PSNP) in Cesarean section (CS) patients. Methods: Data from the Taiwan Longitudinal Health Insurance Database were analyzed. CS patients with a primary diagnosis of PSNP and had at least two ambulatory visits for PSNP treatments were identified as the PSNP subjects. CS patients without PSNP diagnosis were identified as the non-PSNP subjects. The PSNP and non-PSNP subjects were tracked from the surgery date until the end of 2008 or until loss of follow-up. Subjects with a previous history of PSNP before CS, age less than 16 or more than 50 years or missing data of anesthetic mode were excluded. Results: A total of 85 PSNP subjects and 11284 non-PSNP subjects were included. Multivariate logistic regression analyses revealed that diabetes mellitus was a risk factor of PNSP in CS patients [odds ratio (OR)=27, 95{\%} confidence intervals (CI): 15.73 - 46.36; P<O.OOI]. The other risk factors of PSNP in CS patients included age ≧ 35 years (OR=3.25, 95{\%} CI: 2.01. 5.28; P<0.001), hypertension (OR=2.48, 95{\%} CI: 1.12 - 5.50; P=0.026), hyperlipidemia (OR=3.08, 95{\%} CI: 1.29 - 7.39; P=0.012), chronic alcohol exposure (OR=9.61 , 95{\%} CI: 1.53 - 60.27; P=0.016), smoking (OR=3.09, 95{\%} CI: 1.54 - 6.21; P=0.001) and use of antidepressants (OR=7.40, 95{\%} CI: 3.56 - 15.37; P<0.001). Conclusions: The incidence of PSNP in CS patients was 0.74{\%} and the risk factors included DM, age ≧ 35 years, hypertension, hyperlipidemia, chronic alcohol exposure, smoking and use of antidepressants.",
keywords = "剖腹產, 術後神經性疼痛, 風險因子, 族群基礎之研究, Cesarean section, post-surgical neuropathic pam, risk factor, population-based study",
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T1 - Risk Factors of Post-Surgical Neuropathic Pain in Cesarean Section Patients

T2 - A Population-based Study

AU - 李裕祥, null

AU - Meganathan, Nandini

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AU - 黃思誠, null

AU - 蔡佩珊, null

AU - 黃俊仁, null

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N2 - Background: We elucidated the incidence and the risk factors of post-surgical neuropathic pain (PSNP) in Cesarean section (CS) patients. Methods: Data from the Taiwan Longitudinal Health Insurance Database were analyzed. CS patients with a primary diagnosis of PSNP and had at least two ambulatory visits for PSNP treatments were identified as the PSNP subjects. CS patients without PSNP diagnosis were identified as the non-PSNP subjects. The PSNP and non-PSNP subjects were tracked from the surgery date until the end of 2008 or until loss of follow-up. Subjects with a previous history of PSNP before CS, age less than 16 or more than 50 years or missing data of anesthetic mode were excluded. Results: A total of 85 PSNP subjects and 11284 non-PSNP subjects were included. Multivariate logistic regression analyses revealed that diabetes mellitus was a risk factor of PNSP in CS patients [odds ratio (OR)=27, 95% confidence intervals (CI): 15.73 - 46.36; P<O.OOI]. The other risk factors of PSNP in CS patients included age ≧ 35 years (OR=3.25, 95% CI: 2.01. 5.28; P<0.001), hypertension (OR=2.48, 95% CI: 1.12 - 5.50; P=0.026), hyperlipidemia (OR=3.08, 95% CI: 1.29 - 7.39; P=0.012), chronic alcohol exposure (OR=9.61 , 95% CI: 1.53 - 60.27; P=0.016), smoking (OR=3.09, 95% CI: 1.54 - 6.21; P=0.001) and use of antidepressants (OR=7.40, 95% CI: 3.56 - 15.37; P<0.001). Conclusions: The incidence of PSNP in CS patients was 0.74% and the risk factors included DM, age ≧ 35 years, hypertension, hyperlipidemia, chronic alcohol exposure, smoking and use of antidepressants.

AB - Background: We elucidated the incidence and the risk factors of post-surgical neuropathic pain (PSNP) in Cesarean section (CS) patients. Methods: Data from the Taiwan Longitudinal Health Insurance Database were analyzed. CS patients with a primary diagnosis of PSNP and had at least two ambulatory visits for PSNP treatments were identified as the PSNP subjects. CS patients without PSNP diagnosis were identified as the non-PSNP subjects. The PSNP and non-PSNP subjects were tracked from the surgery date until the end of 2008 or until loss of follow-up. Subjects with a previous history of PSNP before CS, age less than 16 or more than 50 years or missing data of anesthetic mode were excluded. Results: A total of 85 PSNP subjects and 11284 non-PSNP subjects were included. Multivariate logistic regression analyses revealed that diabetes mellitus was a risk factor of PNSP in CS patients [odds ratio (OR)=27, 95% confidence intervals (CI): 15.73 - 46.36; P<O.OOI]. The other risk factors of PSNP in CS patients included age ≧ 35 years (OR=3.25, 95% CI: 2.01. 5.28; P<0.001), hypertension (OR=2.48, 95% CI: 1.12 - 5.50; P=0.026), hyperlipidemia (OR=3.08, 95% CI: 1.29 - 7.39; P=0.012), chronic alcohol exposure (OR=9.61 , 95% CI: 1.53 - 60.27; P=0.016), smoking (OR=3.09, 95% CI: 1.54 - 6.21; P=0.001) and use of antidepressants (OR=7.40, 95% CI: 3.56 - 15.37; P<0.001). Conclusions: The incidence of PSNP in CS patients was 0.74% and the risk factors included DM, age ≧ 35 years, hypertension, hyperlipidemia, chronic alcohol exposure, smoking and use of antidepressants.

KW - 剖腹產

KW - 術後神經性疼痛

KW - 風險因子

KW - 族群基礎之研究

KW - Cesarean section

KW - post-surgical neuropathic pam

KW - risk factor

KW - population-based study

M3 - Article

VL - 25

SP - 61

EP - 69

JO - 疼痛醫學雜誌

JF - 疼痛醫學雜誌

SN - 1021-7959

IS - 2

ER -