Risk factors for sudden cardiac death among patients with schizophrenia

Ping Yi Hou, Galen Chin Lun Hung, Jia Rong Jhong, Shang Ying Tsai, Chiao Chicy Chen, Chian Jue Kuo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Introduction: Patients with schizophrenia suffer from excessive premature mortality, and sudden cardiac death (SCD) is receiving growing attention as a potential cause. Aim: The present study investigated the incidence of SCD and its risk factors in a large schizophrenia cohort. Methods: We enrolled a consecutive series of 8264 patients diagnosed with schizophrenia (according to DSM-III-R and DSM-IV criteria) who were admitted to a psychiatric center in northern Taiwan from January 1, 1985 through December 31, 2008. By linking with national mortality database, 64 cases of SCD were identified. The standardized mortality ratio (SMR) for SCD was estimated. The cases were matched with controls randomly selected using risk-set sampling in a 1:2 ratio. A standardized chart review process was used to collect socio-demographic and clinical characteristics and the prescribed drugs for each study subject. Multivariate conditional logistic regression analysis was used to identify correlates of SCD at the index admission and the latest admission. Results: The SMR for SCD was 4.5. For the clinical profiles at the index admission, physical disease (adjusted risk ratio [aRR] = 2.91, P

Original languageEnglish
Article number6488
Pages (from-to)395-401
Number of pages7
JournalSchizophrenia Research
Volume168
Issue number1-2
DOIs
Publication statusPublished - Oct 1 2015

Fingerprint

Sudden Cardiac Death
Schizophrenia
Diagnostic and Statistical Manual of Mental Disorders
Mortality
Premature Mortality
Taiwan
Psychiatry
Cohort Studies
Logistic Models
Odds Ratio
Regression Analysis
Demography
Databases
Pharmaceutical Preparations

Keywords

  • Aggression
  • Antipsychotics
  • Risk factor
  • Schizophrenia
  • Sudden cardiac death

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Hou, P. Y., Hung, G. C. L., Jhong, J. R., Tsai, S. Y., Chen, C. C., & Kuo, C. J. (2015). Risk factors for sudden cardiac death among patients with schizophrenia. Schizophrenia Research, 168(1-2), 395-401. [6488]. https://doi.org/10.1016/j.schres.2015.07.015

Risk factors for sudden cardiac death among patients with schizophrenia. / Hou, Ping Yi; Hung, Galen Chin Lun; Jhong, Jia Rong; Tsai, Shang Ying; Chen, Chiao Chicy; Kuo, Chian Jue.

In: Schizophrenia Research, Vol. 168, No. 1-2, 6488, 01.10.2015, p. 395-401.

Research output: Contribution to journalArticle

Hou, PY, Hung, GCL, Jhong, JR, Tsai, SY, Chen, CC & Kuo, CJ 2015, 'Risk factors for sudden cardiac death among patients with schizophrenia', Schizophrenia Research, vol. 168, no. 1-2, 6488, pp. 395-401. https://doi.org/10.1016/j.schres.2015.07.015
Hou, Ping Yi ; Hung, Galen Chin Lun ; Jhong, Jia Rong ; Tsai, Shang Ying ; Chen, Chiao Chicy ; Kuo, Chian Jue. / Risk factors for sudden cardiac death among patients with schizophrenia. In: Schizophrenia Research. 2015 ; Vol. 168, No. 1-2. pp. 395-401.
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