Risk Factors for Sudden Cardiac Death Among Patients with Alcohol Dependence: A Nested Case-Control Study

Shu I. Wu, Shang Ying Tsai, Ming Chyi Huang, Robert Stewart, Chian Jue Kuo, Chiao Chicy Chen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Excessive alcohol consumption causes a broad range of health problems, including premature mortality and sudden cardiac death (SCD). We identified potential clinical characteristics and laboratory indices associated with SCD among patients with alcohol dependence. Methods: Patients with alcohol dependence (n = 2,793) admitted to a psychiatric center in northern Taiwan between 1985 and 2008 were linked with a national mortality database for causes of death. Of the 2,793 patients in the cohort, 67 cases died of SCD. The standardized mortality ratio (SMR) of SCD relative to the general population was calculated. Based on a nested case-control design, we selected a set of sex-, age-, and year-of-admission-matched two control subjects for each case derived from the cohort. We collated the clinical information through a standardized review of patients' medical records. Conditional logistic regressions were then conducted to explore potential exposures associated with SCD. Results: The sample had substantially higher SCD mortality (SMR 12.8) compared to the general population. After adjustments in the multivariate analyses for the clinical profiles at the index (earliest) admission, both abnormal electrocardiography (ECG) (adjusted risk ratio = 16.97, 95% confidence interval (CI) 1.60 to 179.58, p = 0.019) and elevated aspartate aminotransferase levels (adjusted risk ratio = 1.01, 95% CI 1.00 to 1.02, p = 0.046) were significantly associated with SCD. Conclusions: This study raises the question of whether intensive follow-up of patients with elevated AST and abnormal ECG findings should be evaluated as a strategy to prevent SCD in patients with alcohol dependence.

Original languageEnglish
Pages (from-to)1797-1804
Number of pages8
JournalAlcoholism: Clinical and Experimental Research
Volume39
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

Fingerprint

Sudden Cardiac Death
Alcoholism
Case-Control Studies
Alcohols
Electrocardiography
Mortality
Medical problems
Aspartate Aminotransferases
Logistics
Odds Ratio
Confidence Intervals
Social Adjustment
Premature Mortality
Taiwan
Alcohol Drinking
Population
Medical Records
Psychiatry
Cause of Death
Multivariate Analysis

Keywords

  • Alcohol Dependence
  • Electrocardiography
  • Risk Factor
  • Sudden Cardiac Death

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

Risk Factors for Sudden Cardiac Death Among Patients with Alcohol Dependence : A Nested Case-Control Study. / Wu, Shu I.; Tsai, Shang Ying; Huang, Ming Chyi; Stewart, Robert; Kuo, Chian Jue; Chen, Chiao Chicy.

In: Alcoholism: Clinical and Experimental Research, Vol. 39, No. 9, 01.09.2015, p. 1797-1804.

Research output: Contribution to journalArticle

Wu, Shu I. ; Tsai, Shang Ying ; Huang, Ming Chyi ; Stewart, Robert ; Kuo, Chian Jue ; Chen, Chiao Chicy. / Risk Factors for Sudden Cardiac Death Among Patients with Alcohol Dependence : A Nested Case-Control Study. In: Alcoholism: Clinical and Experimental Research. 2015 ; Vol. 39, No. 9. pp. 1797-1804.
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