Abstract
Information is lacking on the integrated evaluation of mortality rates in healthcare-associated infections (HAIs). Our aim was to differentiate the risk factors responsible for the incidence from those for the case-fatality rates in association with HAIs. We therefore examined the time trends of both incidence and case-fatality rates over a 20-year period at a tertiary-care teaching medical centre in Taiwan and the mortality rate was expressed as the product of the incidence rate and the case-fatality rate. During the study period the overall mortality rate fell from 0 46 to 0 32 deaths/1000 patient-days and the incidence rate fell from 3 41 to 2 31/1000 patient-days, but the case-fatality rate increased marginally from 13 5% to 14 0%. The independent risk factors associated with incidence of HAIs were age, gender, infection site, admission type, and department of hospitalization. Significant prognostic factors for HAI case-fatality were age, infection site, intensive care, and clinical department. We conclude that the decreasing trend for the HAI mortality rate was accompanied by a significant decline in the incidence rate and this was offset by a slightly increasing trend in the case-fatality rate. This deconstruction approach could provide further insights into the underlying complex causes of mortality for HAIs.
| Original language | English |
|---|---|
| Pages (from-to) | 198-206 |
| Number of pages | 9 |
| Journal | Epidemiology and Infection |
| Volume | 144 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2016 |
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Keywords
- Case-fatality
- healthcare-associated infection
- incidence
- incidence-death cohort
ASJC Scopus subject areas
- Epidemiology
- Medicine(all)
- Infectious Diseases
Cite this
Risk factors for incidence and case-fatality rates of healthcare-associated infections : A 20-year follow-up of a hospital-based cohort. / Wang, R. F.; Shen, S. H.; Yen, A. M F; Wang, T. L.; Jang, T. N.; Lee, S. H.; Wang, J. T.; Chen, H. H.
In: Epidemiology and Infection, Vol. 144, No. 1, 01.01.2016, p. 198-206.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk factors for incidence and case-fatality rates of healthcare-associated infections
T2 - A 20-year follow-up of a hospital-based cohort
AU - Wang, R. F.
AU - Shen, S. H.
AU - Yen, A. M F
AU - Wang, T. L.
AU - Jang, T. N.
AU - Lee, S. H.
AU - Wang, J. T.
AU - Chen, H. H.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Information is lacking on the integrated evaluation of mortality rates in healthcare-associated infections (HAIs). Our aim was to differentiate the risk factors responsible for the incidence from those for the case-fatality rates in association with HAIs. We therefore examined the time trends of both incidence and case-fatality rates over a 20-year period at a tertiary-care teaching medical centre in Taiwan and the mortality rate was expressed as the product of the incidence rate and the case-fatality rate. During the study period the overall mortality rate fell from 0 46 to 0 32 deaths/1000 patient-days and the incidence rate fell from 3 41 to 2 31/1000 patient-days, but the case-fatality rate increased marginally from 13 5% to 14 0%. The independent risk factors associated with incidence of HAIs were age, gender, infection site, admission type, and department of hospitalization. Significant prognostic factors for HAI case-fatality were age, infection site, intensive care, and clinical department. We conclude that the decreasing trend for the HAI mortality rate was accompanied by a significant decline in the incidence rate and this was offset by a slightly increasing trend in the case-fatality rate. This deconstruction approach could provide further insights into the underlying complex causes of mortality for HAIs.
AB - Information is lacking on the integrated evaluation of mortality rates in healthcare-associated infections (HAIs). Our aim was to differentiate the risk factors responsible for the incidence from those for the case-fatality rates in association with HAIs. We therefore examined the time trends of both incidence and case-fatality rates over a 20-year period at a tertiary-care teaching medical centre in Taiwan and the mortality rate was expressed as the product of the incidence rate and the case-fatality rate. During the study period the overall mortality rate fell from 0 46 to 0 32 deaths/1000 patient-days and the incidence rate fell from 3 41 to 2 31/1000 patient-days, but the case-fatality rate increased marginally from 13 5% to 14 0%. The independent risk factors associated with incidence of HAIs were age, gender, infection site, admission type, and department of hospitalization. Significant prognostic factors for HAI case-fatality were age, infection site, intensive care, and clinical department. We conclude that the decreasing trend for the HAI mortality rate was accompanied by a significant decline in the incidence rate and this was offset by a slightly increasing trend in the case-fatality rate. This deconstruction approach could provide further insights into the underlying complex causes of mortality for HAIs.
KW - Case-fatality
KW - healthcare-associated infection
KW - incidence
KW - incidence-death cohort
UR - http://www.scopus.com/inward/record.url?scp=84983120336&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983120336&partnerID=8YFLogxK
U2 - 10.1017/S0950268815000369
DO - 10.1017/S0950268815000369
M3 - Article
C2 - 25991064
AN - SCOPUS:84983120336
VL - 144
SP - 198
EP - 206
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
IS - 1
ER -