Risk factors for ectopic pregnancy in the Taiwanese population: A retrospective observational study

Alan Hwang, Leslie Chou, M. M. Islam, Yu Chuan Li, Shabbir Syed-Abdul

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: The aim of this study is to explore the risk factors for ectopic pregnancy (EP) in the Taiwanese population and to identify any unknown risk factors for EP that could assist awareness and diagnosis. Methods: This retrospective case–control study utilizes Taiwan’s National Health Insurance Research Database (NHIRD). Analysis was conducted with a one million sample database representative of the country’s population. The case group comprised of 6637 individuals in the database that coded for EP using the ICD-9 classification system from January 2003 to December 2011. The control group comprised of 13,270 females matched by age that were never diagnosed with EP during the study period. Results: This study provides an analysis of the risk factors of EP utilizing NHIRD. Among the 6637 people diagnosed with EP, logistic regression with age adjustment showed that the highest risk factor was endometriosis (OR = 8.84, CI 5.13–15.23), followed by polycystic ovary (OR = 7.74, CI 3.37–17.79) and benign neoplasm of the ovary (6.01, CI 2.18–16.54). All odds ratios were determined to be statistically significant at p <0.001. Conclusion: This study has identified the diagnosis of endometriosis and polycystic ovaries as the two largest risk factors for EP in Taiwan, and has also newly identified benign neoplasm of ovary and uterine leiomyoma as risk factors for EP.

Original languageEnglish
Pages (from-to)779-783
Number of pages5
JournalArchives of Gynecology and Obstetrics
Volume294
Issue number4
DOIs
Publication statusPublished - Oct 1 2016

Fingerprint

Ectopic Pregnancy
Observational Studies
Retrospective Studies
Population
Ovary
Databases
National Health Programs
Endometriosis
Leiomyoma
International Classification of Diseases
Taiwan
Research
Neoplasms
Logistic Models
Odds Ratio
Control Groups

Keywords

  • Ectopic pregnancy
  • Endometriosis
  • Miscarriage
  • Polycystic ovarian syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Risk factors for ectopic pregnancy in the Taiwanese population : A retrospective observational study. / Hwang, Alan; Chou, Leslie; Islam, M. M.; Li, Yu Chuan; Syed-Abdul, Shabbir.

In: Archives of Gynecology and Obstetrics, Vol. 294, No. 4, 01.10.2016, p. 779-783.

Research output: Contribution to journalArticle

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