Risk factors for early circulatory mortality in patients with schizophrenia

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Patients with schizophrenia have higher mortality and shortened life expectancy than the general population, and cardiovascular disease (CVD) accounts for up to 50% cases of early mortality in schizophrenia. We determined risk factors, particularly pathophysiological changes, for early circulatory mortality in schizophrenia. In this multi-institutional, nested, case–control study, we enrolled consecutive inpatients with schizophrenia admitted to three psychiatric hospitals in the northern Taiwan. Seventy-nine patients who died of CVD before 65 years of age were identified as cases through record linkage, and 158 controls were randomly selected in a 2:1 ratio through risk-set density sampling, after matching for age (±2 years), sex, and index admission (±3 years). Data were obtained through medical record reviews. At the time of death, the mean age of the patients was 47.5 years (standard deviation = 10.3). Conditional logistic regression revealed that the duration of antipsychotic treatment was significantly associated with a lower risk of early circulatory mortality, and leukocyte counts at index hospitalization were significantly associated with a higher risk. Systemic inflammation may be a risk factor for early circulatory mortality in schizophrenia, but antipsychotic treatment, in particular typical antipsychotic treatment, could be a protective factor.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalPsychiatry Research
Volume267
DOIs
Publication statusPublished - Sep 1 2018

Fingerprint

Schizophrenia
Mortality
Antipsychotic Agents
Cardiovascular Diseases
Psychiatric Hospitals
Life Expectancy
Taiwan
Leukocyte Count
Medical Records
Inpatients
Hospitalization
Therapeutics
Logistic Models
Odds Ratio
Inflammation
Population

Keywords

  • Antipsychotics
  • Early circulatory morality
  • Inflammation
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Risk factors for early circulatory mortality in patients with schizophrenia. / Chung, Kuo Hsuan; Chen, Pao Huan; Kuo, Chian Jue; Tsai, Shang Ying; Huang, Shou Hung; Wu, Wen Cheng.

In: Psychiatry Research, Vol. 267, 01.09.2018, p. 7-11.

Research output: Contribution to journalArticle

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