Risk factors for early cardiovascular mortality in patients with bipolar disorder

Shang Ying Tsai, Chao Hsien Lee, Pao Huan Chen, Kuo Hsuan Chung, Shou Hung Huang, Chian Jue Kuo, Cheng Wen Wu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim: We attempted to determine risk factors, particularly pathophysiological changes, for early cardiovascular mortality in bipolar disorder (BD). Methods: A total of 5416 inpatients with bipolar I disorder were retrospectively followed through record linkage for cause of death. A total of 35 patients dying from cardiovascular disease (CVD; ICD 9: 401-443) before the age of 65years were identified. Two living BD patients and two mentally healthy adults were matched with each deceased patient as control subjects according to age (±2years), sex, and date (±3years) of the final/index admission or the date of general health screening. Data were obtained through medical record reviews. Results: Eighty percent of CVD deaths occurred within 10years following the index admission. Conditional logistic regression revealed that the variables most strongly associated with CVD mortality were the leukocyte count and heart rate on the first day of the index hospitalization, as the deceased BD patients were compared with the living BD controls. Systolic pressure on the first day of the index hospitalization can be substituted for heart rate as another risk factor for CVD mortality. Conclusion: It is suggested that systemic inflammation and sympathetic overactivity during the acute phase of BD may be risk factors for early CVD mortality.

Original languageEnglish
JournalPsychiatry and Clinical Neurosciences
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Bipolar Disorder
Mortality
Hospitalization
Heart Rate
International Classification of Diseases
Leukocyte Count
Medical Records
Inpatients
Cause of Death
Cardiovascular Diseases
Logistic Models
Blood Pressure
Inflammation
Health

Keywords

  • Bipolar disorder
  • Cardiovascular disease
  • Inflammation
  • Mortality
  • Sympathetic overactivity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

@article{db22bde3b4664c9a9bc2f15edb42e83f,
title = "Risk factors for early cardiovascular mortality in patients with bipolar disorder",
abstract = "Aim: We attempted to determine risk factors, particularly pathophysiological changes, for early cardiovascular mortality in bipolar disorder (BD). Methods: A total of 5416 inpatients with bipolar I disorder were retrospectively followed through record linkage for cause of death. A total of 35 patients dying from cardiovascular disease (CVD; ICD 9: 401-443) before the age of 65years were identified. Two living BD patients and two mentally healthy adults were matched with each deceased patient as control subjects according to age (±2years), sex, and date (±3years) of the final/index admission or the date of general health screening. Data were obtained through medical record reviews. Results: Eighty percent of CVD deaths occurred within 10years following the index admission. Conditional logistic regression revealed that the variables most strongly associated with CVD mortality were the leukocyte count and heart rate on the first day of the index hospitalization, as the deceased BD patients were compared with the living BD controls. Systolic pressure on the first day of the index hospitalization can be substituted for heart rate as another risk factor for CVD mortality. Conclusion: It is suggested that systemic inflammation and sympathetic overactivity during the acute phase of BD may be risk factors for early CVD mortality.",
keywords = "Bipolar disorder, Cardiovascular disease, Inflammation, Mortality, Sympathetic overactivity",
author = "Tsai, {Shang Ying} and Lee, {Chao Hsien} and Chen, {Pao Huan} and Chung, {Kuo Hsuan} and Huang, {Shou Hung} and Kuo, {Chian Jue} and Wu, {Cheng Wen}",
year = "2017",
doi = "10.1111/pcn.12538",
language = "English",
journal = "Psychiatry and Clinical Neurosciences",
issn = "1323-1316",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Risk factors for early cardiovascular mortality in patients with bipolar disorder

AU - Tsai, Shang Ying

AU - Lee, Chao Hsien

AU - Chen, Pao Huan

AU - Chung, Kuo Hsuan

AU - Huang, Shou Hung

AU - Kuo, Chian Jue

AU - Wu, Cheng Wen

PY - 2017

Y1 - 2017

N2 - Aim: We attempted to determine risk factors, particularly pathophysiological changes, for early cardiovascular mortality in bipolar disorder (BD). Methods: A total of 5416 inpatients with bipolar I disorder were retrospectively followed through record linkage for cause of death. A total of 35 patients dying from cardiovascular disease (CVD; ICD 9: 401-443) before the age of 65years were identified. Two living BD patients and two mentally healthy adults were matched with each deceased patient as control subjects according to age (±2years), sex, and date (±3years) of the final/index admission or the date of general health screening. Data were obtained through medical record reviews. Results: Eighty percent of CVD deaths occurred within 10years following the index admission. Conditional logistic regression revealed that the variables most strongly associated with CVD mortality were the leukocyte count and heart rate on the first day of the index hospitalization, as the deceased BD patients were compared with the living BD controls. Systolic pressure on the first day of the index hospitalization can be substituted for heart rate as another risk factor for CVD mortality. Conclusion: It is suggested that systemic inflammation and sympathetic overactivity during the acute phase of BD may be risk factors for early CVD mortality.

AB - Aim: We attempted to determine risk factors, particularly pathophysiological changes, for early cardiovascular mortality in bipolar disorder (BD). Methods: A total of 5416 inpatients with bipolar I disorder were retrospectively followed through record linkage for cause of death. A total of 35 patients dying from cardiovascular disease (CVD; ICD 9: 401-443) before the age of 65years were identified. Two living BD patients and two mentally healthy adults were matched with each deceased patient as control subjects according to age (±2years), sex, and date (±3years) of the final/index admission or the date of general health screening. Data were obtained through medical record reviews. Results: Eighty percent of CVD deaths occurred within 10years following the index admission. Conditional logistic regression revealed that the variables most strongly associated with CVD mortality were the leukocyte count and heart rate on the first day of the index hospitalization, as the deceased BD patients were compared with the living BD controls. Systolic pressure on the first day of the index hospitalization can be substituted for heart rate as another risk factor for CVD mortality. Conclusion: It is suggested that systemic inflammation and sympathetic overactivity during the acute phase of BD may be risk factors for early CVD mortality.

KW - Bipolar disorder

KW - Cardiovascular disease

KW - Inflammation

KW - Mortality

KW - Sympathetic overactivity

UR - http://www.scopus.com/inward/record.url?scp=85021224285&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021224285&partnerID=8YFLogxK

U2 - 10.1111/pcn.12538

DO - 10.1111/pcn.12538

M3 - Article

AN - SCOPUS:85021224285

JO - Psychiatry and Clinical Neurosciences

JF - Psychiatry and Clinical Neurosciences

SN - 1323-1316

ER -