Risk factors for colorectal cancer in Taiwan

A hospital-based case-control study

Chih Ching Yeh, Ling Ling Hsieh, Reiping Tang, Chung Rong Chang-Chieh, Fung Chang Sung

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background and Purpose: There have been few studies of the risk factors associated with colorectal cancer in Taiwan, a country of low incidence of the disease. This study investigated whether dietary and lifestyle factors correlate with colorectal cancer risks in Taiwan. Methods: A total of 352 patients with colon cancer and 375 patients with rectal cancer histologically confirmed between 1995 to 1999 at a medical center in northern Taiwan were included in the study. They were age and gender-matched with 736 healthy controls who were recruited from the health examination clinic at the same hospital. Dietary intake and lifestyle variables were ascertained using a standardized questionnaire. Unconditional multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: The risk of colon cancer and of rectal cancer was inversely associated with vegetable/fruit consumption in both men and women. The adjusted ORs based on the highest versus the lowest tertile consumption were 0.36 (95% CI, 0.21 to 0.61) and 0.44 (95% CI, 0.27 to 0.72) for men, respectively. The corresponding ORs for women were 0.32 (95% CI, 0.19 to 0.56) and 0.39 (95% CI, 0.23 to 0.69), respectively. However, the highest versus the lowest tertile meat consumption was associated with significantly elevated risk in both and women for both colon cancer (ORs, 1.85 and 2.29, respectively) and rectal cancer (ORs, 2.32 and 2.42, respectively). Risk also increased with less exercise, low or moderated coffee consumption, cigarette smoking and alcohol intake, and decreased with the frequency of fish/shrimp consumption among men. Conclusions: Consistent with the findings of previous studies in Western populations, this study found that vegetable and fruit consumption, less meat consumption, and exercise were associated with a reduced incidence of colorectal cancer in Taiwanese.

Original languageEnglish
Pages (from-to)305-312
Number of pages8
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume102
Issue number5
Publication statusPublished - May 1 2003
Externally publishedYes

Fingerprint

Taiwan
Case-Control Studies
Colorectal Neoplasms
Odds Ratio
Confidence Intervals
Rectal Neoplasms
Colonic Neoplasms
Vegetables
Meat
Life Style
Fruit
Exercise
Coffee
Incidence
Fishes
Logistic Models
Smoking
Alcohols
Health
Population

Keywords

  • Colorectal neoplasms
  • Diet
  • Nutrition
  • Risk factors
  • Taiwan

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Risk factors for colorectal cancer in Taiwan : A hospital-based case-control study. / Yeh, Chih Ching; Hsieh, Ling Ling; Tang, Reiping; Chang-Chieh, Chung Rong; Sung, Fung Chang.

In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 102, No. 5, 01.05.2003, p. 305-312.

Research output: Contribution to journalArticle

Yeh, Chih Ching ; Hsieh, Ling Ling ; Tang, Reiping ; Chang-Chieh, Chung Rong ; Sung, Fung Chang. / Risk factors for colorectal cancer in Taiwan : A hospital-based case-control study. In: Journal of the Formosan Medical Association = Taiwan yi zhi. 2003 ; Vol. 102, No. 5. pp. 305-312.
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AU - Hsieh, Ling Ling

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AU - Chang-Chieh, Chung Rong

AU - Sung, Fung Chang

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AB - Background and Purpose: There have been few studies of the risk factors associated with colorectal cancer in Taiwan, a country of low incidence of the disease. This study investigated whether dietary and lifestyle factors correlate with colorectal cancer risks in Taiwan. Methods: A total of 352 patients with colon cancer and 375 patients with rectal cancer histologically confirmed between 1995 to 1999 at a medical center in northern Taiwan were included in the study. They were age and gender-matched with 736 healthy controls who were recruited from the health examination clinic at the same hospital. Dietary intake and lifestyle variables were ascertained using a standardized questionnaire. Unconditional multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: The risk of colon cancer and of rectal cancer was inversely associated with vegetable/fruit consumption in both men and women. The adjusted ORs based on the highest versus the lowest tertile consumption were 0.36 (95% CI, 0.21 to 0.61) and 0.44 (95% CI, 0.27 to 0.72) for men, respectively. The corresponding ORs for women were 0.32 (95% CI, 0.19 to 0.56) and 0.39 (95% CI, 0.23 to 0.69), respectively. However, the highest versus the lowest tertile meat consumption was associated with significantly elevated risk in both and women for both colon cancer (ORs, 1.85 and 2.29, respectively) and rectal cancer (ORs, 2.32 and 2.42, respectively). Risk also increased with less exercise, low or moderated coffee consumption, cigarette smoking and alcohol intake, and decreased with the frequency of fish/shrimp consumption among men. Conclusions: Consistent with the findings of previous studies in Western populations, this study found that vegetable and fruit consumption, less meat consumption, and exercise were associated with a reduced incidence of colorectal cancer in Taiwanese.

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KW - Diet

KW - Nutrition

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KW - Colorectal neoplasms

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