Risk factors correlated with risk of insulin resistance using homeostasis model assessment in adolescents in Taiwan

Shiyng-Yu Lin, Chien-Tien Su, Yi-Chen Hsieh, Yu Ling Li, Yih Ru Chen, Shu Yun Cheng, Chien Ming Hu, Yi-Hua Chen, Fang-I Hsieh, Hung-Yi Chiou

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Abstract

The study aims to discover risk factors significantly correlated with insulin resistance among adolescents in Taiwan. A total of 339 study subjects were recruited in this cross-sectional study. A self-administered questionnaire and physical examinations including anthropometrics and biochemistry profiles were collected. Insulin resistance was assessed using homeostasis model assessment for insulin resistance (HOMA-IR). Study subjects had a significantly increased risk of IR for those with abnormal level of body mass index (odds ratio [OR] = 3.54; 95% confidence interval [CI] = 1.81-6.91), body fat (OR = 2.71; 95% CI = 1.25-5.88), and waist circumference (OR = 25.04; 95% CI = 2.93-214.14) when compared with those who have normal values. Furthermore, a significantly joint effect of 10.86-fold risk for HOMA-IR abnormality among body fat, body mass index, and systolic blood pressure was observed. The identification of risk factors significantly correlated with IR will be important to prevent metabolic syndrome-related diseases and complications for adolescents in their future life.

Original languageEnglish
Pages (from-to)NP476-NP484
JournalAsia-Pacific Journal of Public Health
Volume27
Issue number2
DOIs
Publication statusPublished - Mar 4 2015

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Keywords

  • adolescents
  • HOMA-IR
  • insulin resistance
  • metabolic syndrome
  • risk factors

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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