Risk factors and microbiological features of patients hospitalized for microbial keratitis: A 10-year study in a referral center in Taiwan

Tzu Yu Lin, Lung Kun Yeh, David H.K. Ma, Phil Y.F. Chen, Hsin Chiung Lin, Chi Chin Sun, Hsin Yuan Tan, Hung Chi Chen, Shin Yi Chen, Ching Hsi Hsiao

Research output: Contribution to journalArticle

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Abstract

We conducted a retrospective, cross-sectional study to analyze predisposing factors, clinical features, and microbiological characteristics of patients with microbial keratitis hospitalized over 10 years. The medical records of 558 patients who were diagnosed with microbial keratitis and admitted to Chang Gung Memorial Hospital (CGMH), a referral center in Taiwan, from January 1,2003 to December 31, 2012 were reviewed. Demographics, predisposing factors, isolated organisms, treatment, and hospital stay were recorded. Yearly trends were tested using a linear-by-linear association. Contact lens wear was the most common predisposing factor (31.4%), followed by ocular and systemic diseases (26.3%) and trauma (23.5%). Contact lens-related infectious keratitis increased year by year (P = 0.011). Pseudomonas aeruginosa was the most commonly isolated organism (28%), followed by fungi (17.6%) and coagulase-negative Staphylococcus (5.4%). Except for Serratia marcescens, the identified organisms did not change over 10 years. Most bacterial infections were controlled using antimicrobial treatment, but more than half of patients with fungal keratitis required surgical interventions. The mean hospital stay was 13.7 ±11.5 days. Previous ocular surgery, large ulcer size, nontuberculous myycobacteris infection, and surgery during admission were related to prolonged hospital stay. In Taiwan, contact lens-related pseudomonal keratitis remained the most common cause of microbial keratitis in patients hospitalized from 2003 to 2012.

Original languageEnglish
Article numbere1905
JournalMedicine (United States)
Volume94
Issue number43
DOIs
Publication statusPublished - Jan 1 2015

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Keratitis
antineoplaston A10
Taiwan
Referral and Consultation
Contact Lenses
Causality
Length of Stay
Serratia marcescens
Eye Diseases
Coagulase
Staphylococcus
Bacterial Infections
Pseudomonas aeruginosa
Ulcer
Medical Records
Fungi
Cross-Sectional Studies
Demography
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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Risk factors and microbiological features of patients hospitalized for microbial keratitis : A 10-year study in a referral center in Taiwan. / Lin, Tzu Yu; Yeh, Lung Kun; Ma, David H.K.; Chen, Phil Y.F.; Lin, Hsin Chiung; Sun, Chi Chin; Tan, Hsin Yuan; Chen, Hung Chi; Chen, Shin Yi; Hsiao, Ching Hsi.

In: Medicine (United States), Vol. 94, No. 43, e1905, 01.01.2015.

Research output: Contribution to journalArticle

Lin, Tzu Yu ; Yeh, Lung Kun ; Ma, David H.K. ; Chen, Phil Y.F. ; Lin, Hsin Chiung ; Sun, Chi Chin ; Tan, Hsin Yuan ; Chen, Hung Chi ; Chen, Shin Yi ; Hsiao, Ching Hsi. / Risk factors and microbiological features of patients hospitalized for microbial keratitis : A 10-year study in a referral center in Taiwan. In: Medicine (United States). 2015 ; Vol. 94, No. 43.
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