Risk estimates for drugs suspected of being associated with Stevens-Johnson syndrome and toxic epidermal necrolysis: A case-control study

M. S. Lin, Y. S. Dai, R. F. Pwu, Y. H. Chen, Nen Chung Chang

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The purpose of this case-control study is to estimate the risks of Stevens-Johnson syndrome or toxic epidermal necrolysis associated with the use of specific drugs. The suspected cases were identified from the computerized hospital discharge file. We calculated crude relative risks and adjusted them for confounding by multivariate analysis. The analysis was based on 35 cases and 105 controls. This study showed that the use of carbamazepine, phenytoin and allopurinol is most associated with the risks in the oriental population.

Original languageEnglish
Pages (from-to)188-190
Number of pages3
JournalInternal Medicine Journal
Volume35
Issue number3
DOIs
Publication statusPublished - Mar 2005

Keywords

  • Adverse drug reaction
  • Case-control study
  • Relative risk
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis

ASJC Scopus subject areas

  • Internal Medicine

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