Risk estimates for drugs suspected of being associated with Stevens-Johnson syndrome and toxic epidermal necrolysis: A case-control study

M. S. Lin, Y. S. Dai, R. F. Pwu, Y. H. Chen, Nen Chung Chang

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The purpose of this case-control study is to estimate the risks of Stevens-Johnson syndrome or toxic epidermal necrolysis associated with the use of specific drugs. The suspected cases were identified from the computerized hospital discharge file. We calculated crude relative risks and adjusted them for confounding by multivariate analysis. The analysis was based on 35 cases and 105 controls. This study showed that the use of carbamazepine, phenytoin and allopurinol is most associated with the risks in the oriental population.

Original languageEnglish
Pages (from-to)188-190
Number of pages3
JournalInternal Medicine Journal
Volume35
Issue number3
DOIs
Publication statusPublished - Mar 2005

Fingerprint

Stevens-Johnson Syndrome
Case-Control Studies
Pharmaceutical Preparations
Allopurinol
Carbamazepine
Phenytoin
Multivariate Analysis
Population

Keywords

  • Adverse drug reaction
  • Case-control study
  • Relative risk
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Risk estimates for drugs suspected of being associated with Stevens-Johnson syndrome and toxic epidermal necrolysis : A case-control study. / Lin, M. S.; Dai, Y. S.; Pwu, R. F.; Chen, Y. H.; Chang, Nen Chung.

In: Internal Medicine Journal, Vol. 35, No. 3, 03.2005, p. 188-190.

Research output: Contribution to journalArticle

@article{4de5ac8734ba42419bb8edeec3870e5f,
title = "Risk estimates for drugs suspected of being associated with Stevens-Johnson syndrome and toxic epidermal necrolysis: A case-control study",
abstract = "The purpose of this case-control study is to estimate the risks of Stevens-Johnson syndrome or toxic epidermal necrolysis associated with the use of specific drugs. The suspected cases were identified from the computerized hospital discharge file. We calculated crude relative risks and adjusted them for confounding by multivariate analysis. The analysis was based on 35 cases and 105 controls. This study showed that the use of carbamazepine, phenytoin and allopurinol is most associated with the risks in the oriental population.",
keywords = "Adverse drug reaction, Case-control study, Relative risk, Stevens-Johnson syndrome, Toxic epidermal necrolysis",
author = "Lin, {M. S.} and Dai, {Y. S.} and Pwu, {R. F.} and Chen, {Y. H.} and Chang, {Nen Chung}",
year = "2005",
month = "3",
doi = "10.1111/j.1445-5994.2005.00790.x",
language = "English",
volume = "35",
pages = "188--190",
journal = "Internal Medicine Journal",
issn = "1444-0903",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Risk estimates for drugs suspected of being associated with Stevens-Johnson syndrome and toxic epidermal necrolysis

T2 - A case-control study

AU - Lin, M. S.

AU - Dai, Y. S.

AU - Pwu, R. F.

AU - Chen, Y. H.

AU - Chang, Nen Chung

PY - 2005/3

Y1 - 2005/3

N2 - The purpose of this case-control study is to estimate the risks of Stevens-Johnson syndrome or toxic epidermal necrolysis associated with the use of specific drugs. The suspected cases were identified from the computerized hospital discharge file. We calculated crude relative risks and adjusted them for confounding by multivariate analysis. The analysis was based on 35 cases and 105 controls. This study showed that the use of carbamazepine, phenytoin and allopurinol is most associated with the risks in the oriental population.

AB - The purpose of this case-control study is to estimate the risks of Stevens-Johnson syndrome or toxic epidermal necrolysis associated with the use of specific drugs. The suspected cases were identified from the computerized hospital discharge file. We calculated crude relative risks and adjusted them for confounding by multivariate analysis. The analysis was based on 35 cases and 105 controls. This study showed that the use of carbamazepine, phenytoin and allopurinol is most associated with the risks in the oriental population.

KW - Adverse drug reaction

KW - Case-control study

KW - Relative risk

KW - Stevens-Johnson syndrome

KW - Toxic epidermal necrolysis

UR - http://www.scopus.com/inward/record.url?scp=15244341936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15244341936&partnerID=8YFLogxK

U2 - 10.1111/j.1445-5994.2005.00790.x

DO - 10.1111/j.1445-5994.2005.00790.x

M3 - Article

C2 - 15737140

AN - SCOPUS:15244341936

VL - 35

SP - 188

EP - 190

JO - Internal Medicine Journal

JF - Internal Medicine Journal

SN - 1444-0903

IS - 3

ER -