Risk analysis of malignant potential of oral verrucous hyperplasia: A follow-up study of 269 patients and copy number variation analysis

Ming Heng Wu, Ji Dung Luo, Wen Chang Wang, Tzu Hao Chang, Wei Lun Hwang, Kuen Haur Lee, Shyun Yeu Liu, Jung Wu Yang, Chang Ta Chiou, Chi Hua Chang, Wei Fan Chiang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Oral verrucous hyperplasia is commonly observed in the oral cavity of betel quid chewers and is a potential malignant disorder. However, the prognostic factors and genetic alterations of oral verrucous hyperplasia are unclear. Methods: We calculate the survival rate and prognostic factors using a Kaplan-Meier analysis and Cox proportional hazards regression model. Copy number variations were analyzed using a single-nucleotide polymorphism (SNP) array. Results: The 5-year disease-free and cancer-free survival rates of patients with oral verrucous hyperplasia were approximately 40% and 70%, respectively. Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions were risk factors for malignant transformation, whereas dysplasia did not affect outcomes. The gene amplification of CTTN, FOLR3, ORAOV1, PPFIA1, and RNF121 were associated with the poor prognosis of oral verrucous hyperplasia. Conclusion: Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions are high-risk factors of patients with oral verrucous hyperplasia. The 5-copy number variation-associated genes could be used for early diagnosis and predicting the prognosis.

Original languageEnglish
JournalHead and Neck
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Hyperplasia
Oral Submucous Fibrosis
Mastication
Survival Rate
Gene Amplification
Kaplan-Meier Estimate
Proportional Hazards Models
Single Nucleotide Polymorphism
Mouth
Early Diagnosis
Genes
Neoplasms

Keywords

  • Betel quid chewer
  • Copy number variation
  • Malignant transformation
  • Oral submucous fibrosis
  • Oral verrucous hyperplasia

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Risk analysis of malignant potential of oral verrucous hyperplasia : A follow-up study of 269 patients and copy number variation analysis. / Wu, Ming Heng; Luo, Ji Dung; Wang, Wen Chang; Chang, Tzu Hao; Hwang, Wei Lun; Lee, Kuen Haur; Liu, Shyun Yeu; Yang, Jung Wu; Chiou, Chang Ta; Chang, Chi Hua; Chiang, Wei Fan.

In: Head and Neck, 01.01.2018.

Research output: Contribution to journalArticle

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abstract = "Background: Oral verrucous hyperplasia is commonly observed in the oral cavity of betel quid chewers and is a potential malignant disorder. However, the prognostic factors and genetic alterations of oral verrucous hyperplasia are unclear. Methods: We calculate the survival rate and prognostic factors using a Kaplan-Meier analysis and Cox proportional hazards regression model. Copy number variations were analyzed using a single-nucleotide polymorphism (SNP) array. Results: The 5-year disease-free and cancer-free survival rates of patients with oral verrucous hyperplasia were approximately 40{\%} and 70{\%}, respectively. Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions were risk factors for malignant transformation, whereas dysplasia did not affect outcomes. The gene amplification of CTTN, FOLR3, ORAOV1, PPFIA1, and RNF121 were associated with the poor prognosis of oral verrucous hyperplasia. Conclusion: Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions are high-risk factors of patients with oral verrucous hyperplasia. The 5-copy number variation-associated genes could be used for early diagnosis and predicting the prognosis.",
keywords = "Betel quid chewer, Copy number variation, Malignant transformation, Oral submucous fibrosis, Oral verrucous hyperplasia",
author = "Wu, {Ming Heng} and Luo, {Ji Dung} and Wang, {Wen Chang} and Chang, {Tzu Hao} and Hwang, {Wei Lun} and Lee, {Kuen Haur} and Liu, {Shyun Yeu} and Yang, {Jung Wu} and Chiou, {Chang Ta} and Chang, {Chi Hua} and Chiang, {Wei Fan}",
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AU - Luo, Ji Dung

AU - Wang, Wen Chang

AU - Chang, Tzu Hao

AU - Hwang, Wei Lun

AU - Lee, Kuen Haur

AU - Liu, Shyun Yeu

AU - Yang, Jung Wu

AU - Chiou, Chang Ta

AU - Chang, Chi Hua

AU - Chiang, Wei Fan

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N2 - Background: Oral verrucous hyperplasia is commonly observed in the oral cavity of betel quid chewers and is a potential malignant disorder. However, the prognostic factors and genetic alterations of oral verrucous hyperplasia are unclear. Methods: We calculate the survival rate and prognostic factors using a Kaplan-Meier analysis and Cox proportional hazards regression model. Copy number variations were analyzed using a single-nucleotide polymorphism (SNP) array. Results: The 5-year disease-free and cancer-free survival rates of patients with oral verrucous hyperplasia were approximately 40% and 70%, respectively. Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions were risk factors for malignant transformation, whereas dysplasia did not affect outcomes. The gene amplification of CTTN, FOLR3, ORAOV1, PPFIA1, and RNF121 were associated with the poor prognosis of oral verrucous hyperplasia. Conclusion: Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions are high-risk factors of patients with oral verrucous hyperplasia. The 5-copy number variation-associated genes could be used for early diagnosis and predicting the prognosis.

AB - Background: Oral verrucous hyperplasia is commonly observed in the oral cavity of betel quid chewers and is a potential malignant disorder. However, the prognostic factors and genetic alterations of oral verrucous hyperplasia are unclear. Methods: We calculate the survival rate and prognostic factors using a Kaplan-Meier analysis and Cox proportional hazards regression model. Copy number variations were analyzed using a single-nucleotide polymorphism (SNP) array. Results: The 5-year disease-free and cancer-free survival rates of patients with oral verrucous hyperplasia were approximately 40% and 70%, respectively. Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions were risk factors for malignant transformation, whereas dysplasia did not affect outcomes. The gene amplification of CTTN, FOLR3, ORAOV1, PPFIA1, and RNF121 were associated with the poor prognosis of oral verrucous hyperplasia. Conclusion: Heavy betel quid chewing, advanced oral submucous fibrosis, and nonbuccal and nontongue lesions are high-risk factors of patients with oral verrucous hyperplasia. The 5-copy number variation-associated genes could be used for early diagnosis and predicting the prognosis.

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KW - Malignant transformation

KW - Oral submucous fibrosis

KW - Oral verrucous hyperplasia

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