Ring chromosome in a case of acute myelomonocytic leukemia: Its significance and a review of the literature

J. Whang-Peng, E. C. Lee, C. S. Kao-Shan, G. Schechter

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

The presence of ring chromosomes is a rare finding in patients with de novo acute nonlymphocytic leukemia (ANLL). In this report we describe the cytogenetic abnormalities, including ring chromosomes, of a 45-year-old white male who had ANLL of the myelomonocytic type (M4). All of the leukemic cells had both a small unidentified ring and a medium-sized ring which was derived from chromosomes 2 and 11, r(2;11)(2p25;11p15q23;2q37). Four different types of rings or other structural abnormalities were derived from this medium-sized ring. A review of the literature indicated that the median survival of ANLL patients with either identified or unidentified ring chromosomes was 5 to 6 months, and that the presence of these cytogenetic abnormalities was related to a poor prognosis.

Original languageEnglish
Pages (from-to)57-65
Number of pages9
JournalHematologic Pathology
Volume1
Issue number1
Publication statusPublished - Dec 1 1987
Externally publishedYes

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Leukemia, Myelomonocytic, Acute
Ring Chromosomes
Acute Myeloid Leukemia
Chromosome Aberrations
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 2
Survival

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Hematology

Cite this

Ring chromosome in a case of acute myelomonocytic leukemia : Its significance and a review of the literature. / Whang-Peng, J.; Lee, E. C.; Kao-Shan, C. S.; Schechter, G.

In: Hematologic Pathology, Vol. 1, No. 1, 01.12.1987, p. 57-65.

Research output: Contribution to journalReview article

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