Right lower prefronto-parietal cortical dysfunction in akinetic catatonia: A combined study of neuropsychology and regional cerebral blood flow

Georg Northoff, R. Steinke, D. Nagel, C. Czerwenka, O. Grosser, P. Danos, A. Genz, R. Krause, H. Böker, H. J. Otto, B. Bogerts

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background. Catatonia is a psychomotor syndrome that can be characterized by behavioural, affective and motor abnormalities. In order to reveal further underlying pathophysiological mechanisms of psychomotor disturbances in catatonia we investigated neuropsychological function and regional cerebral perfusion (r-CBF) in a combined study. Methods. Ten catatonic patients were investigated with Tc-99mECD brain SPECT and compared with 10 psychiatric (similar age, sex, medication and underlying psychiatric diagnosis but without catatonic syndrome) and 20 healthy controls. Neuropsychological measures included tests for general intelligence, attention, executive functions and right parietal visual-spatial abilities. Correlational analyses were performed between neuropsychological measures, catatonic symptoms and r-CBF. Results. Catatonic patients showed a significant decrease of r-CBF in right lower and middle prefrontal and parietal cortex compared with psychiatric and healthy controls as well as significantly poorer performance in visual-spatial abilities associated with right parietal function. Correlational analysis revealed significant correlations between visual-spatial abilities and right parietal r-CBF only in psychiatric and healthy controls but not in catatonic patients. In contrast, attentional measures correlated significantly with motor symptoms, visual-spatial abilities and right parietal r-CBF in catatonia only but not in psychiatric or in healthy controls. Conclusion. Findings are preliminary but suggest right lower prefronto-parietal cortical dysfunction in catatonia, which may be closely related to psychomotor disturbances.

Original languageEnglish
Pages (from-to)583-596
Number of pages14
JournalPsychological Medicine
Volume30
Issue number3
DOIs
Publication statusPublished - 2000

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Cerebrovascular Circulation
Catatonia
Neuropsychology
Regional Blood Flow
Perfusion
Psychiatry
Parietal Lobe
Intelligence Tests
Executive Function
Prefrontal Cortex
Single-Photon Emission-Computed Tomography
Mental Disorders
Spatial Navigation
Brain

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Right lower prefronto-parietal cortical dysfunction in akinetic catatonia : A combined study of neuropsychology and regional cerebral blood flow. / Northoff, Georg; Steinke, R.; Nagel, D.; Czerwenka, C.; Grosser, O.; Danos, P.; Genz, A.; Krause, R.; Böker, H.; Otto, H. J.; Bogerts, B.

In: Psychological Medicine, Vol. 30, No. 3, 2000, p. 583-596.

Research output: Contribution to journalArticle

Northoff, G, Steinke, R, Nagel, D, Czerwenka, C, Grosser, O, Danos, P, Genz, A, Krause, R, Böker, H, Otto, HJ & Bogerts, B 2000, 'Right lower prefronto-parietal cortical dysfunction in akinetic catatonia: A combined study of neuropsychology and regional cerebral blood flow', Psychological Medicine, vol. 30, no. 3, pp. 583-596. https://doi.org/10.1017/S0033291799002007
Northoff, Georg ; Steinke, R. ; Nagel, D. ; Czerwenka, C. ; Grosser, O. ; Danos, P. ; Genz, A. ; Krause, R. ; Böker, H. ; Otto, H. J. ; Bogerts, B. / Right lower prefronto-parietal cortical dysfunction in akinetic catatonia : A combined study of neuropsychology and regional cerebral blood flow. In: Psychological Medicine. 2000 ; Vol. 30, No. 3. pp. 583-596.
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