Rice Bran Reduces Weight Gain and Modulates Lipid Metabolism in Rats with High-Energy-Diet-Induced Obesity

Suh Ching Yang, Wen Ching Huang, Xin Er Ng, Mon Chien Lee, Yi Ju Hsu, Chi Chang Huang, Hai Hsin Wu, Chiu Li Yeh, Hitoshi Shirakawa, Slamet Budijanto, Te Hsuan Tung, Yu Tang Tung

Research output: Contribution to journalArticle

Abstract

Obesity has become an epidemic worldwide. It is a complex metabolic disorder associated with many serious complications and high morbidity. Rice bran is a nutrient-dense by product of the rice milling process. Asia has the world's highest rice production (90% of the world's rice production); therefore, rice bran is inexpensive in Asian countries. Moreover, the high nutritional value of the rice bran suggests its potential as a food supplement promoting health improvements, such as enhancing brain function, lowering blood pressure, and regulating pancreatic secretion. The present study evaluated the anti-obesity effect of rice bran in rats with high-energy diet (HED)-induced obesity. Male Sprague-Dawley rats were randomly divided into one of five diet groups (n = 10 per group) and fed the following for eight weeks: Normal diet with vehicle treatment, HED with vehicle, rice bran-0.5X (RB-0.5X) (2% wt/wt rice bran), RB-1.0X (4% wt/wt rice bran), and RB-2.0X (8% wt/wt rice bran). Rice bran (RB-1.0X and RB-2.0X groups) markedly reduced obesity, including body weight and adipocyte size. In addition, treating rats with HED-induced obesity using rice bran significantly reduced the serum uric acid and glucose as well as the liver triglyceride (TG) and total cholesterol (TC). Furthermore, administration of an HED to obese rats significantly affected hepatic lipid homeostasis by increasing phosphotidylcholine (PC; 18:2/22:6), diacylglycerol (DG; 18:2/16:0), DG (18:2/18:1), DG (18:1/16:0), cholesteryl ester (CE; 20:5), CE (28:2), TG (18:0/16:0/18:3), and glycerol-1-2-hexadecanoate 3-octadecanoate. However, the rice bran treatment demonstrated an anti-adiposity effect by partially reducing the HED-induced DG (18:2/18:1) and TG (18:0/16:0/18:3) increases in obese rats. In conclusion, rice bran could act as an anti-obesity supplement in rats, as demonstrated by partially reducing the HED-induced DG and TG increases in obese rats, and thus limit the metabolic diseases associated with obesity and the accumulation of body fat and hepatic lipids in rats.

Original languageEnglish
Pages (from-to)2033
JournalNutrients
Volume11
Issue number9
DOIs
Publication statusPublished - Aug 30 2019

Fingerprint

high energy diet
rice bran
Lipid Metabolism
lipid metabolism
Weight Gain
obesity
Obesity
weight gain
Diet
rats
triacylglycerols
Triglycerides
metabolic diseases
liver
Oryza
rice products
Liver
rice
health promotion
cholesteryl esters

Keywords

  • high-energy diet (HED)
  • lipid metabolism
  • lipidomics
  • obesity
  • rice bran

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Rice Bran Reduces Weight Gain and Modulates Lipid Metabolism in Rats with High-Energy-Diet-Induced Obesity. / Yang, Suh Ching; Huang, Wen Ching; Ng, Xin Er; Lee, Mon Chien; Hsu, Yi Ju; Huang, Chi Chang; Wu, Hai Hsin; Yeh, Chiu Li; Shirakawa, Hitoshi; Budijanto, Slamet; Tung, Te Hsuan; Tung, Yu Tang.

In: Nutrients, Vol. 11, No. 9, 30.08.2019, p. 2033.

Research output: Contribution to journalArticle

Yang, SC, Huang, WC, Ng, XE, Lee, MC, Hsu, YJ, Huang, CC, Wu, HH, Yeh, CL, Shirakawa, H, Budijanto, S, Tung, TH & Tung, YT 2019, 'Rice Bran Reduces Weight Gain and Modulates Lipid Metabolism in Rats with High-Energy-Diet-Induced Obesity', Nutrients, vol. 11, no. 9, pp. 2033. https://doi.org/10.3390/nu11092033
Yang, Suh Ching ; Huang, Wen Ching ; Ng, Xin Er ; Lee, Mon Chien ; Hsu, Yi Ju ; Huang, Chi Chang ; Wu, Hai Hsin ; Yeh, Chiu Li ; Shirakawa, Hitoshi ; Budijanto, Slamet ; Tung, Te Hsuan ; Tung, Yu Tang. / Rice Bran Reduces Weight Gain and Modulates Lipid Metabolism in Rats with High-Energy-Diet-Induced Obesity. In: Nutrients. 2019 ; Vol. 11, No. 9. pp. 2033.
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AU - Huang, Chi Chang

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