Rhombic-shaped channel stent with enhanced drug capacity and fatigue life

Hao Ming Hsiao, Cheng Han Lin, Yung Kang Shen, Tzu Yun Chou, Yen Yu Hsu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A drug-eluting stent with rhombic-shaped drug reservoirs is proposed, aimed at providing long-term drug delivery and enhanced fatigue life. Unique rhombic-shaped reservoirs or channels on the stent struts can increase the total drug capacity and improve the stress distribution for longer fatigue life, without compromising other important clinical attributes. Our rhombic-shaped channel stent increases the total drug capacity by multiple times. Its fatigue safety factor, even with the large rhombic cutouts on the stent struts, could be 50% higher than that of the conventional drug-eluting stent. A pulsed fiber-optic laser and a series of expansions and heat treatments were used to make the first prototype of our rhombic-shaped channel stent. This new concept may open up a wide variety of new treatment options and opportunities for the medical industry in the future.

Original languageEnglish
Article number3
JournalMicromachines
Volume9
Issue number1
DOIs
Publication statusPublished - Dec 24 2017

Fingerprint

Stents
Fatigue of materials
Struts
Safety factor
Drug delivery
Fiber optics
Stress concentration
Heat treatment
Lasers
Industry

Keywords

  • Channel stent
  • Depot stent
  • Drug-eluting stent
  • Programmable drug delivery
  • Rhombic-shaped drug reservoir

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

Rhombic-shaped channel stent with enhanced drug capacity and fatigue life. / Hsiao, Hao Ming; Lin, Cheng Han; Shen, Yung Kang; Chou, Tzu Yun; Hsu, Yen Yu.

In: Micromachines, Vol. 9, No. 1, 3, 24.12.2017.

Research output: Contribution to journalArticle

Hsiao, Hao Ming ; Lin, Cheng Han ; Shen, Yung Kang ; Chou, Tzu Yun ; Hsu, Yen Yu. / Rhombic-shaped channel stent with enhanced drug capacity and fatigue life. In: Micromachines. 2017 ; Vol. 9, No. 1.
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