Retrospective Study of False-positive Breast Magnetic Resonance Images and Pathological Results in Taiwan

Ting-Kai Leung, Pai Jung Huang, Hung Hua Liang, Chin Sheng Hung, Ching Shyang Chen, Jan Show Chu, Hui Yu Liou, Chi-Ming Lee, Chih Hsiung Wu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Breast magnetic resonance imaging (MRI) is extremely sensitive for detecting lesions, but certain characteristics of malignancies, such as the washout pattern of kinetic curves, are not specific. Correlations of false-positive MRI and specific pathological results are worthy of study. Methods: From March 2008 to September 2011, 217 cases received biopsy after dedicated breast MRI in our department. Biopsies were recommended for suspected malignancies based on the overall analysis of early subtracted phase images, postenhanced curve patterns, color mapping, and tumor morphology. Results: Twenty-nine percent of cases were false positive for malignancy, according to MRI. These lesions included radial scar, apocrine metaplasia, atypical ductal hyperplasia, sclerosing adenosis, intraductal papilloma, fibrocystic change, and mastitis. Conclusion: The ability of tumor cells to induce vascularization occurs early in the cell transformation process; therefore, premalignant breast lesions may also induce vascularization to facilitate malignant transformation. As a noninvasive method, contrast-enhanced MRI has a potential role in estimating the degree of angiogenesis and tumor microvascular permeability of breast neoplasms.

Original languageEnglish
Pages (from-to)284-288
Number of pages5
JournalJournal of Experimental and Clinical Medicine(Taiwan)
Volume4
Issue number5
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Taiwan
Breast
Magnetic Resonance Spectroscopy
Retrospective Studies
Magnetic Resonance Imaging
Neoplasms
Intraductal Papilloma
Biopsy
Carcinoma, Intraductal, Noninfiltrating
Mastitis
Metaplasia
Capillary Permeability
Cicatrix
Color
Breast Neoplasms

Keywords

  • Dedicated breast magnetic resonance imaging
  • False-positive results
  • Pathology
  • Tumor microvascularity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Retrospective Study of False-positive Breast Magnetic Resonance Images and Pathological Results in Taiwan. / Leung, Ting-Kai; Huang, Pai Jung; Liang, Hung Hua; Hung, Chin Sheng; Chen, Ching Shyang; Chu, Jan Show; Liou, Hui Yu; Lee, Chi-Ming; Wu, Chih Hsiung.

In: Journal of Experimental and Clinical Medicine(Taiwan), Vol. 4, No. 5, 10.2012, p. 284-288.

Research output: Contribution to journalArticle

Leung, Ting-Kai ; Huang, Pai Jung ; Liang, Hung Hua ; Hung, Chin Sheng ; Chen, Ching Shyang ; Chu, Jan Show ; Liou, Hui Yu ; Lee, Chi-Ming ; Wu, Chih Hsiung. / Retrospective Study of False-positive Breast Magnetic Resonance Images and Pathological Results in Taiwan. In: Journal of Experimental and Clinical Medicine(Taiwan). 2012 ; Vol. 4, No. 5. pp. 284-288.
@article{b56634f761d1498db0d9232a37ddf461,
title = "Retrospective Study of False-positive Breast Magnetic Resonance Images and Pathological Results in Taiwan",
abstract = "Background: Breast magnetic resonance imaging (MRI) is extremely sensitive for detecting lesions, but certain characteristics of malignancies, such as the washout pattern of kinetic curves, are not specific. Correlations of false-positive MRI and specific pathological results are worthy of study. Methods: From March 2008 to September 2011, 217 cases received biopsy after dedicated breast MRI in our department. Biopsies were recommended for suspected malignancies based on the overall analysis of early subtracted phase images, postenhanced curve patterns, color mapping, and tumor morphology. Results: Twenty-nine percent of cases were false positive for malignancy, according to MRI. These lesions included radial scar, apocrine metaplasia, atypical ductal hyperplasia, sclerosing adenosis, intraductal papilloma, fibrocystic change, and mastitis. Conclusion: The ability of tumor cells to induce vascularization occurs early in the cell transformation process; therefore, premalignant breast lesions may also induce vascularization to facilitate malignant transformation. As a noninvasive method, contrast-enhanced MRI has a potential role in estimating the degree of angiogenesis and tumor microvascular permeability of breast neoplasms.",
keywords = "Dedicated breast magnetic resonance imaging, False-positive results, Pathology, Tumor microvascularity",
author = "Ting-Kai Leung and Huang, {Pai Jung} and Liang, {Hung Hua} and Hung, {Chin Sheng} and Chen, {Ching Shyang} and Chu, {Jan Show} and Liou, {Hui Yu} and Chi-Ming Lee and Wu, {Chih Hsiung}",
year = "2012",
month = "10",
doi = "10.1016/j.jecm.2012.09.005",
language = "English",
volume = "4",
pages = "284--288",
journal = "Journal of Experimental and Clinical Medicine",
issn = "1878-3317",
publisher = "Elsevier Taiwan LLC",
number = "5",

}

TY - JOUR

T1 - Retrospective Study of False-positive Breast Magnetic Resonance Images and Pathological Results in Taiwan

AU - Leung, Ting-Kai

AU - Huang, Pai Jung

AU - Liang, Hung Hua

AU - Hung, Chin Sheng

AU - Chen, Ching Shyang

AU - Chu, Jan Show

AU - Liou, Hui Yu

AU - Lee, Chi-Ming

AU - Wu, Chih Hsiung

PY - 2012/10

Y1 - 2012/10

N2 - Background: Breast magnetic resonance imaging (MRI) is extremely sensitive for detecting lesions, but certain characteristics of malignancies, such as the washout pattern of kinetic curves, are not specific. Correlations of false-positive MRI and specific pathological results are worthy of study. Methods: From March 2008 to September 2011, 217 cases received biopsy after dedicated breast MRI in our department. Biopsies were recommended for suspected malignancies based on the overall analysis of early subtracted phase images, postenhanced curve patterns, color mapping, and tumor morphology. Results: Twenty-nine percent of cases were false positive for malignancy, according to MRI. These lesions included radial scar, apocrine metaplasia, atypical ductal hyperplasia, sclerosing adenosis, intraductal papilloma, fibrocystic change, and mastitis. Conclusion: The ability of tumor cells to induce vascularization occurs early in the cell transformation process; therefore, premalignant breast lesions may also induce vascularization to facilitate malignant transformation. As a noninvasive method, contrast-enhanced MRI has a potential role in estimating the degree of angiogenesis and tumor microvascular permeability of breast neoplasms.

AB - Background: Breast magnetic resonance imaging (MRI) is extremely sensitive for detecting lesions, but certain characteristics of malignancies, such as the washout pattern of kinetic curves, are not specific. Correlations of false-positive MRI and specific pathological results are worthy of study. Methods: From March 2008 to September 2011, 217 cases received biopsy after dedicated breast MRI in our department. Biopsies were recommended for suspected malignancies based on the overall analysis of early subtracted phase images, postenhanced curve patterns, color mapping, and tumor morphology. Results: Twenty-nine percent of cases were false positive for malignancy, according to MRI. These lesions included radial scar, apocrine metaplasia, atypical ductal hyperplasia, sclerosing adenosis, intraductal papilloma, fibrocystic change, and mastitis. Conclusion: The ability of tumor cells to induce vascularization occurs early in the cell transformation process; therefore, premalignant breast lesions may also induce vascularization to facilitate malignant transformation. As a noninvasive method, contrast-enhanced MRI has a potential role in estimating the degree of angiogenesis and tumor microvascular permeability of breast neoplasms.

KW - Dedicated breast magnetic resonance imaging

KW - False-positive results

KW - Pathology

KW - Tumor microvascularity

UR - http://www.scopus.com/inward/record.url?scp=84869090778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869090778&partnerID=8YFLogxK

U2 - 10.1016/j.jecm.2012.09.005

DO - 10.1016/j.jecm.2012.09.005

M3 - Article

AN - SCOPUS:84869090778

VL - 4

SP - 284

EP - 288

JO - Journal of Experimental and Clinical Medicine

JF - Journal of Experimental and Clinical Medicine

SN - 1878-3317

IS - 5

ER -