Retrograde localization of the innervation of the middle cerebral artery with horseradish peroxidase in cats

S. H. Tsai, S. Z. Lin, S. D. Wang, J. C. Liu, C. J. Shih

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The innervation of the middle cerebral artery (MCA) of the cat was studied by applying horseradish peroxidase (HRP) to the wall of the right MCA. After a survival period of 48 to 72 hours, the bilateral superior cervical ganglia, middle cervical ganglia, stellate ganglia, T-4 sympathetic paravertebral ganglia, geniculate ganglia, semilunar ganglia, nodose ganglia, and brain stem including midbrain, pons, and medulla oblongata were removed to be processed with tetramethyl benzidine. HRP-labeled neurons were found in the ipsilateral superior cervical ganglion, semilunar ganglion, and dorsal raphe nucleus. The other areas did not have HRP activity. The results suggest that the adrenergic nerves innervating the MCA originate in the ipsilateral superior cervical ganglion, the sensory nerve originate in the ipsilateral semilunar ganglion, and the serotonergic nerves originate in the ipsilateral dorsal raphe nucleus. Cerebral arterial constriction may relate to the intrinsic (intracerebral) neurogenic pathway involving the trigeminal nerve and the dorsal raphe nucleus.

Original languageEnglish
Pages (from-to)463-467
Number of pages5
JournalNeurosurgery
Volume16
Issue number4
Publication statusPublished - 1985
Externally publishedYes

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Trigeminal Ganglion
Superior Cervical Ganglion
Middle Cerebral Artery
Horseradish Peroxidase
Cats
Geniculate Ganglion
Nodose Ganglion
Stellate Ganglion
Medulla Oblongata
Sympathetic Ganglia
Trigeminal Nerve
Pons
Mesencephalon
Constriction
Ganglia
Adrenergic Agents
Brain Stem
Neurons
Dorsal Raphe Nucleus

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Retrograde localization of the innervation of the middle cerebral artery with horseradish peroxidase in cats. / Tsai, S. H.; Lin, S. Z.; Wang, S. D.; Liu, J. C.; Shih, C. J.

In: Neurosurgery, Vol. 16, No. 4, 1985, p. 463-467.

Research output: Contribution to journalArticle

Tsai, S. H. ; Lin, S. Z. ; Wang, S. D. ; Liu, J. C. ; Shih, C. J. / Retrograde localization of the innervation of the middle cerebral artery with horseradish peroxidase in cats. In: Neurosurgery. 1985 ; Vol. 16, No. 4. pp. 463-467.
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