Retention of chromosome 3 in extrapulmonary small cell cancer shown by molecular and cytogenetic studies

Bruce E. Johnson, Jacqueline Whang-peng, Susan L. Naylor, Berton Zbar, Hiltrud Brauch, Elaine Lee, Alfreda Simmons, Edward Russell, Myong H. Nam, Adi F. Gazdar

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

In small cell lung carcinoma, one of the short arms of chromosome 3 is typically lost. To investigate chromosome 3 in extrapulmonary small cell carcinoma, we used DNA probes that detect restriction-fragment-length polymorphisms at loci on 3p. These probes were used to study DNA extracted from tumors and normal tissues and/or tumor cell lines from five patients with extrapulmonary small cell cancer. Tumor DNA from four of the five patients with extrapulmonary small cell cancer retained heterozygosity at loci on 3p. Cytogenetic studies of the tumor cell lines established from these four patients showed retention of both short arms of chromosome 3. We conclude that the loss of genetic material from 3p observed in small cell lung cancer is not typical in extrapulmonary small cell cancer. [J Natl Cancer Inst 81:1223-1228, 1989].

Original languageEnglish
Pages (from-to)1223-1228
Number of pages6
JournalJournal of the National Cancer Institute
Volume81
Issue number16
DOIs
Publication statusPublished - Aug 16 1989
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 3
Cytogenetics
Neoplasms
Small Cell Lung Carcinoma
Tumor Cell Line
Small Cell Carcinoma
DNA
DNA Probes
Restriction Fragment Length Polymorphisms
Genes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Retention of chromosome 3 in extrapulmonary small cell cancer shown by molecular and cytogenetic studies. / Johnson, Bruce E.; Whang-peng, Jacqueline; Naylor, Susan L.; Zbar, Berton; Brauch, Hiltrud; Lee, Elaine; Simmons, Alfreda; Russell, Edward; Nam, Myong H.; Gazdar, Adi F.

In: Journal of the National Cancer Institute, Vol. 81, No. 16, 16.08.1989, p. 1223-1228.

Research output: Contribution to journalArticle

Johnson, BE, Whang-peng, J, Naylor, SL, Zbar, B, Brauch, H, Lee, E, Simmons, A, Russell, E, Nam, MH & Gazdar, AF 1989, 'Retention of chromosome 3 in extrapulmonary small cell cancer shown by molecular and cytogenetic studies', Journal of the National Cancer Institute, vol. 81, no. 16, pp. 1223-1228. https://doi.org/10.1093/jnci/81.16.1223
Johnson, Bruce E. ; Whang-peng, Jacqueline ; Naylor, Susan L. ; Zbar, Berton ; Brauch, Hiltrud ; Lee, Elaine ; Simmons, Alfreda ; Russell, Edward ; Nam, Myong H. ; Gazdar, Adi F. / Retention of chromosome 3 in extrapulmonary small cell cancer shown by molecular and cytogenetic studies. In: Journal of the National Cancer Institute. 1989 ; Vol. 81, No. 16. pp. 1223-1228.
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abstract = "In small cell lung carcinoma, one of the short arms of chromosome 3 is typically lost. To investigate chromosome 3 in extrapulmonary small cell carcinoma, we used DNA probes that detect restriction-fragment-length polymorphisms at loci on 3p. These probes were used to study DNA extracted from tumors and normal tissues and/or tumor cell lines from five patients with extrapulmonary small cell cancer. Tumor DNA from four of the five patients with extrapulmonary small cell cancer retained heterozygosity at loci on 3p. Cytogenetic studies of the tumor cell lines established from these four patients showed retention of both short arms of chromosome 3. We conclude that the loss of genetic material from 3p observed in small cell lung cancer is not typical in extrapulmonary small cell cancer. [J Natl Cancer Inst 81:1223-1228, 1989].",
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