Resveratrol protects against physical fatigue and improves exercise performance in mice

Ruei Er Wu, Wen Ching Huang, Chen Chung Liao, Yu Kai Chang, Nai Wen Kan, Chi Chang Huang

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Resveratrol (RES) is a well-known phytocompound and food component which has antioxidative and multifunctional bioactivities. However, there is limited evidence for the effects of RES on physical fatigue and exercise performance. The purpose of this study was to evaluate the potential beneficial effects of trans-RES on fatigue and ergogenic functions following physiological challenge. Male ICR mice from four groups (n = 8 per group) were orally administered RES for 21 days at 0, 25, 50, and 125 mg/kg/day, which were respectively designated the vehicle, RES-25, RES-50, and RES-125 groups. The anti-fatigue activity and exercise performance were evaluated using forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after a 15-min swimming exercise. The exhaustive swimming time of the RES-25 group (24.72 ± 7.35 min) was significantly (p = 0.0179) longer than that of vehicle group (10.83 ± 1.15 min). A trend analysis revealed that RES treatments increased the grip strength. RES supplementation also produced dose-dependent decreases in serum lactate and ammonia levels and CK activity and also an increase in glucose levels in dose-dependent manners after the 15-min swimming test. The mechanism was related to the increased energy utilization (as blood glucose), and decreased serum levels of lactate, ammonia, and CK. Therefore, RES could be a potential agent with an anti-fatigue pharmacological effect.

Original languageEnglish
Pages (from-to)4689-4702
Number of pages14
JournalMolecules
Volume18
Issue number4
DOIs
Publication statusPublished - Apr 2013

Fingerprint

physical exercise
Fatigue
mice
creatine
lactates
Fatigue of materials
glucose
serums
ammonia
vehicles
Creatine Kinase
trend analysis
dosage
Lactic Acid
Hand Strength
food
blood
Ammonia
resveratrol
Serum

Keywords

  • Ammonia
  • Anti-fatigue
  • Creatine kinase
  • Exercise performance
  • Forelimb grip strength
  • Resveratrol

ASJC Scopus subject areas

  • Organic Chemistry
  • Medicine(all)

Cite this

Resveratrol protects against physical fatigue and improves exercise performance in mice. / Wu, Ruei Er; Huang, Wen Ching; Liao, Chen Chung; Chang, Yu Kai; Kan, Nai Wen; Huang, Chi Chang.

In: Molecules, Vol. 18, No. 4, 04.2013, p. 4689-4702.

Research output: Contribution to journalArticle

Wu, Ruei Er ; Huang, Wen Ching ; Liao, Chen Chung ; Chang, Yu Kai ; Kan, Nai Wen ; Huang, Chi Chang. / Resveratrol protects against physical fatigue and improves exercise performance in mice. In: Molecules. 2013 ; Vol. 18, No. 4. pp. 4689-4702.
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