Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo

An Sheng Cheng, Yu Hsiang Cheng, Chi Ying Lee, Chin Yuan Chung, Wen Chang Chang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Methylglyoxal (MG) has been found to cause inflammation and insulin resistance in vitro and in vivo in recent studies. Resveratrol has been proposed as an effective treatment that helps lower the risk of developing complications of diabetes. To study the significance of glycosylation-related stress on the pathology of diabetes, the effects of resveratrol were examined in a mouse model of diabetes induced by MG. Resveratrol was given via oral gavage in MG-treated mice, and diabetes-related tests and markers were assessed using biochemical and immunohistochemical analyses. Treatment with resveratrol markedly improved blood glucose level from the oral glucose tolerance test and promoted nuclear factor erythroid 2-related factor-2 (Nrf2) phosphorylation (p < 0.05) in the pancreas of MG-treated mice. However, these effects were abolished by retinoic acid, Nrf2 inhibitor, in resveratrol and retinoic acid-treated and MG-induced mice. These findings support that resveratrol may be useful in the treatment of type-2 diabetes by protecting against pancreatic cell dysfunction.

Original languageEnglish
Pages (from-to)2850-2865
Number of pages16
JournalNutrients
Volume7
Issue number4
DOIs
Publication statusPublished - Apr 15 2015
Externally publishedYes

Fingerprint

Pyruvaldehyde
resveratrol
hyperglycemia
Hyperglycemia
diabetes
retinoic acid
Tretinoin
mice
Diabetes Complications
glycosylation
Glucose Tolerance Test
in vivo studies
Glycosylation
noninsulin-dependent diabetes mellitus
insulin resistance
pancreas
Type 2 Diabetes Mellitus
blood glucose
Insulin Resistance
Blood Glucose

Keywords

  • Diabetes
  • Methylglyoxal
  • Nuclear factor erythroid 2-related factor 2
  • Resveratrol
  • Retinoic acid

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo. / Cheng, An Sheng; Cheng, Yu Hsiang; Lee, Chi Ying; Chung, Chin Yuan; Chang, Wen Chang.

In: Nutrients, Vol. 7, No. 4, 15.04.2015, p. 2850-2865.

Research output: Contribution to journalArticle

Cheng, An Sheng ; Cheng, Yu Hsiang ; Lee, Chi Ying ; Chung, Chin Yuan ; Chang, Wen Chang. / Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo. In: Nutrients. 2015 ; Vol. 7, No. 4. pp. 2850-2865.
@article{cceac62680854bd5aac2d1b01e881830,
title = "Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo",
abstract = "Methylglyoxal (MG) has been found to cause inflammation and insulin resistance in vitro and in vivo in recent studies. Resveratrol has been proposed as an effective treatment that helps lower the risk of developing complications of diabetes. To study the significance of glycosylation-related stress on the pathology of diabetes, the effects of resveratrol were examined in a mouse model of diabetes induced by MG. Resveratrol was given via oral gavage in MG-treated mice, and diabetes-related tests and markers were assessed using biochemical and immunohistochemical analyses. Treatment with resveratrol markedly improved blood glucose level from the oral glucose tolerance test and promoted nuclear factor erythroid 2-related factor-2 (Nrf2) phosphorylation (p < 0.05) in the pancreas of MG-treated mice. However, these effects were abolished by retinoic acid, Nrf2 inhibitor, in resveratrol and retinoic acid-treated and MG-induced mice. These findings support that resveratrol may be useful in the treatment of type-2 diabetes by protecting against pancreatic cell dysfunction.",
keywords = "Diabetes, Methylglyoxal, Nuclear factor erythroid 2-related factor 2, Resveratrol, Retinoic acid",
author = "Cheng, {An Sheng} and Cheng, {Yu Hsiang} and Lee, {Chi Ying} and Chung, {Chin Yuan} and Chang, {Wen Chang}",
year = "2015",
month = "4",
day = "15",
doi = "10.3390/nu7042850",
language = "English",
volume = "7",
pages = "2850--2865",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",

}

TY - JOUR

T1 - Resveratrol protects against methylglyoxal-induced hyperglycemia and pancreatic damage in vivo

AU - Cheng, An Sheng

AU - Cheng, Yu Hsiang

AU - Lee, Chi Ying

AU - Chung, Chin Yuan

AU - Chang, Wen Chang

PY - 2015/4/15

Y1 - 2015/4/15

N2 - Methylglyoxal (MG) has been found to cause inflammation and insulin resistance in vitro and in vivo in recent studies. Resveratrol has been proposed as an effective treatment that helps lower the risk of developing complications of diabetes. To study the significance of glycosylation-related stress on the pathology of diabetes, the effects of resveratrol were examined in a mouse model of diabetes induced by MG. Resveratrol was given via oral gavage in MG-treated mice, and diabetes-related tests and markers were assessed using biochemical and immunohistochemical analyses. Treatment with resveratrol markedly improved blood glucose level from the oral glucose tolerance test and promoted nuclear factor erythroid 2-related factor-2 (Nrf2) phosphorylation (p < 0.05) in the pancreas of MG-treated mice. However, these effects were abolished by retinoic acid, Nrf2 inhibitor, in resveratrol and retinoic acid-treated and MG-induced mice. These findings support that resveratrol may be useful in the treatment of type-2 diabetes by protecting against pancreatic cell dysfunction.

AB - Methylglyoxal (MG) has been found to cause inflammation and insulin resistance in vitro and in vivo in recent studies. Resveratrol has been proposed as an effective treatment that helps lower the risk of developing complications of diabetes. To study the significance of glycosylation-related stress on the pathology of diabetes, the effects of resveratrol were examined in a mouse model of diabetes induced by MG. Resveratrol was given via oral gavage in MG-treated mice, and diabetes-related tests and markers were assessed using biochemical and immunohistochemical analyses. Treatment with resveratrol markedly improved blood glucose level from the oral glucose tolerance test and promoted nuclear factor erythroid 2-related factor-2 (Nrf2) phosphorylation (p < 0.05) in the pancreas of MG-treated mice. However, these effects were abolished by retinoic acid, Nrf2 inhibitor, in resveratrol and retinoic acid-treated and MG-induced mice. These findings support that resveratrol may be useful in the treatment of type-2 diabetes by protecting against pancreatic cell dysfunction.

KW - Diabetes

KW - Methylglyoxal

KW - Nuclear factor erythroid 2-related factor 2

KW - Resveratrol

KW - Retinoic acid

UR - http://www.scopus.com/inward/record.url?scp=84927915781&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927915781&partnerID=8YFLogxK

U2 - 10.3390/nu7042850

DO - 10.3390/nu7042850

M3 - Article

VL - 7

SP - 2850

EP - 2865

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 4

ER -