Resveratrol increases stem cell function in the treatment of damaged pancreas

Tung Sheng Chen, Chia Hua Kuo, Cecilia Hsuan Day, Lung Fa Pan, Ray Jade Chen, Bih Cheng Chen, Vijaya V. Padma, Yueh Min Lin, Chih Yang Huang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Pancreatic damage results in insufficient insulin secretion, leading to type 1 diabetes. Stem cell-based therapy has recently shown potential in the treatment of type 1 diabetes. Resveratrol supplementation has demonstrated a beneficial effect in treating diabetes. This study investigates if adipose-derived stem cells (ADSC), preconditioned with resveratrol, show better effects on experimental diabetic animals. Wistar rats were randomly divided into four groups including sham (normal rats), DM (diabetic rats induced by SZT injection), DM+ADSC (DM rats with receiving autologous ADSC transplantation) and DM+R-ADSC (DM rats receiving resveratrol preconditioned ADSC). The experimental results show that SZT induced pancreatic damage (DM group), including reduction of islet size, fibrosis pathway activation, survival signaling suppression, and apoptotic pathway expression, lead to serum glucose elevation. Autologous ADSC (DM+ADSC group) transplantation shows improvement in the above observations in DM rats. Furthermore, ADSC precondition with resveratrol (DM+R-ADSC group) reveals significant improvement in the above pathological observations over both DM and DM+ADSC groups. We found that ADSC precondition with resveratrol increases the survival marker p-Akt expression, leading to enhanced ADSC viability. This study suggests that ADSC precondition with resveratrol shows potential in the treatment of patients with type 1 DM.

Original languageEnglish
Pages (from-to)20443-20452
Number of pages10
JournalJournal of Cellular Physiology
Volume234
Issue number11
DOIs
Publication statusPublished - Nov 2019

    Fingerprint

Keywords

  • diabetes
  • mesenchymal stem cells
  • pancreatic damage
  • resveratrol

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Chen, T. S., Kuo, C. H., Day, C. H., Pan, L. F., Chen, R. J., Chen, B. C., Padma, V. V., Lin, Y. M., & Huang, C. Y. (2019). Resveratrol increases stem cell function in the treatment of damaged pancreas. Journal of Cellular Physiology, 234(11), 20443-20452. https://doi.org/10.1002/jcp.28646