Resveratrol enhances therapeutic effect on pancreatic regeneration in diabetes mellitus rats receiving autologous transplantation of adipose-derived stem cells

Tung Sheng Chen, Pei Fang Lai, Pei Fang Lai, Chia Hua Kuo, Cecilia Day, Ray Jade Chen, Tsung Jung Ho, Yu Lan Yeh, Yu Lan Yeh, B. Mahalakshmi, Vijaya Padmaviswanadha, Wei Wen Kuo, Chih Yang Huang, Chih Yang Huang, Chih Yang Huang, Chih Yang Huang

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Pancreatic damage is the major causative agent in type 1 diabetes mellitus (DM). Several strategies have been suggested to regenerate pancreatic functions, such as stem cell transplantation and administration of active components isolating from natural herbals. This study aims to investigate if the synergistically protective effect on damaged pancreatic tissues can be observed in STZ-induced DM rats with autologous transplantation of adipose-derived stem cells (ADSC) coupling with oral administration of resveratrol. Pathological conditions can be recognized in DM rats with pancreatic damage, including reduction of islet size, suppression of survival markers, downregulation of AMPK/Sirt1 axis, and activation of apoptotic signaling. Autologous transplantation of ADSC slightly improves pancreatic functions, whereas autologous transplantation of ADSC coupling with oral administration of resveratrol significantly improves pancreatic functions in DM rats. We suggest that oral administration of resveratrol may enhance the therapeutic effect on DM patients receiving autologous transplantation of ADSC.

Original languageEnglish
Pages (from-to)122-127
Number of pages6
JournalChinese Journal of Physiology
Volume63
Issue number3
DOIs
Publication statusPublished - May 1 2020

Keywords

  • Diabetes
  • mesenchymal stem cells
  • pancreas
  • resveratrol

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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