Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells

Ya Chen Ko, Chia Ling Chang, Hsiung-Fei Chien, Ching-Hsiang Wu, Liang In Lin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.

Original languageEnglish
Pages (from-to)46-53
Number of pages8
JournalCancer Letters
Volume309
Issue number1
DOIs
Publication statusPublished - Oct 1 2011
Externally publishedYes

Keywords

  • Anaplastic large-cell lymphoma
  • Apoptosis
  • Differentiation
  • Fas/CD95
  • Resveratrol
  • SR-786

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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