Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells

Ya Chen Ko, Chia Ling Chang, Hsiung-Fei Chien, Ching-Hsiang Wu, Liang In Lin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.

Original languageEnglish
Pages (from-to)46-53
Number of pages8
JournalCancer Letters
Volume309
Issue number1
DOIs
Publication statusPublished - Oct 1 2011
Externally publishedYes

Fingerprint

Anaplastic Large-Cell Lymphoma
Death Domain Receptors
Apoptosis
Stilbenes
Differentiation Antigens
Vitis
DNA Fragmentation
resveratrol
Cell Differentiation
Atherosclerosis
Cell Cycle
Carcinogenesis
T-Lymphocytes
Cell Line
Growth

Keywords

  • Anaplastic large-cell lymphoma
  • Apoptosis
  • Differentiation
  • Fas/CD95
  • Resveratrol
  • SR-786

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells. / Ko, Ya Chen; Chang, Chia Ling; Chien, Hsiung-Fei; Wu, Ching-Hsiang; Lin, Liang In.

In: Cancer Letters, Vol. 309, No. 1, 01.10.2011, p. 46-53.

Research output: Contribution to journalArticle

@article{1dfed19ca6e449ed8dabdf74992b0d31,
title = "Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells",
abstract = "Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.",
keywords = "Anaplastic large-cell lymphoma, Apoptosis, Differentiation, Fas/CD95, Resveratrol, SR-786",
author = "Ko, {Ya Chen} and Chang, {Chia Ling} and Hsiung-Fei Chien and Ching-Hsiang Wu and Lin, {Liang In}",
year = "2011",
month = "10",
day = "1",
doi = "10.1016/j.canlet.2011.05.014",
language = "English",
volume = "309",
pages = "46--53",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Resveratrol enhances the expression of death receptor Fas/CD95 and induces differentiation and apoptosis in anaplastic large-cell lymphoma cells

AU - Ko, Ya Chen

AU - Chang, Chia Ling

AU - Chien, Hsiung-Fei

AU - Wu, Ching-Hsiang

AU - Lin, Liang In

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.

AB - Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other plants, plays a protective role in human atherosclerosis and carcinogenesis. We examined the effects of resveratrol on the anaplastic large-cell lymphoma (ALCL) cell line SR-786. Resveratrol inhibited growth and induced cellular differentiation, as demonstrated by morphological changes and elevated expression of T cell differentiation markers CD2, CD3, and CD8. Resveratrol also triggered cellular apoptosis, as demonstrated by morphological observations, DNA fragmentation, and cell cycle analyses. Further, the surface expression of the death receptor Fas/CD95 was increased by resveratrol treatment. Our data suggest that resveratrol may have potential therapeutic value for ALCL.

KW - Anaplastic large-cell lymphoma

KW - Apoptosis

KW - Differentiation

KW - Fas/CD95

KW - Resveratrol

KW - SR-786

UR - http://www.scopus.com/inward/record.url?scp=79959834010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959834010&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2011.05.014

DO - 10.1016/j.canlet.2011.05.014

M3 - Article

C2 - 21683516

AN - SCOPUS:79959834010

VL - 309

SP - 46

EP - 53

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -