Resveratrol, a red wine antioxidant, reduces atrial fibrillation susceptibility in the failing heart by PI3K/AKT/eNOS signaling pathway activation

Eric Chong, Shih Lin Chang, Ya Wen Hsiao, Rahul Singhal, Shuen Hsin Liu, Trung Leha, Wen Yu Lin, Chiao Po Hsu, Yao Chang Chen, Yi Jen Chen, Tsu Juey Wu, Satoshi Higa, Shih Ann Chen

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37 Citations (Scopus)

Abstract

Background Resveratrol has shown benefits in reducing ventricular remodeling and arrhythmias. Objective This study aimed to assess the therapeutic efficacy of resveratrol in reducing atrial fibrillation (AF) in a heart failure (HF) model and to explore the underlying mechanisms. Methods HF rabbits were created 4 weeks after undergoing coronary ligation. Group 1 (n = 6) was divided into subgroups of (a) normal rabbits, (b) HF sham rabbits, and (c) HF rabbits treated for 1 week with intraperitoneal injections of resveratrol, (d) resveratrol plus wortmannin, or (e) resveratrol plus diphenyleneiodonium chloride (DPI). All rabbits underwent epicardial catheter stimulation. Collagen content, messenger RNA and protein expression in ion channels, and phosphoinositide 3-kinase (PI3K)/AKT/endothelial nitric oxide synthase (eNOS) signaling pathways were studied in left atrial appendage (LAA) preparations. To investigate acute drug effects on left atrial electrophysiology, groups 2 a through 2e (n = 6 per group) were subjected to Langendorff perfusion. Results Higher AF inducibility was found in the HF group and groups that were given PI3K and eNOS inhibitors than in the normal and resveratrol-treated groups (P

Original languageEnglish
Article number6115
Pages (from-to)1046-1056
Number of pages11
JournalHeart Rhythm
Volume12
Issue number5
DOIs
Publication statusPublished - May 1 2015

Keywords

  • Atrial fibrillation
  • Ion channel
  • Resveratrol
  • Signaling pathway

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Chong, E., Chang, S. L., Hsiao, Y. W., Singhal, R., Liu, S. H., Leha, T., Lin, W. Y., Hsu, C. P., Chen, Y. C., Chen, Y. J., Wu, T. J., Higa, S., & Chen, S. A. (2015). Resveratrol, a red wine antioxidant, reduces atrial fibrillation susceptibility in the failing heart by PI3K/AKT/eNOS signaling pathway activation. Heart Rhythm, 12(5), 1046-1056. [6115]. https://doi.org/10.1016/j.hrthm.2015.01.044