Resting state low-frequency fluctuations in prefrontal cortex reflect degrees of harm avoidance and novelty seeking

An exploratory NIRS study

Takashi Nakao, Tomoya Matsumoto, Daisuke Shimizu, Machiko Morita, Shinpei Yoshimura, Georg Northoff, Shigeru Morinobu, Yasumasa Okamoto, Shigeto Yamawaki

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Harm avoidance (HA) and novelty seeking (NS) are temperament dimensions defined by Temperament and Character Inventory (TCI), respectively, reflecting a heritable bias for intense response to aversive stimuli or for excitement in response to novel stimuli. High HA is regarded as a risk factor for major depressive disorder and anxiety disorder. In contrast, higher NS is linked to increased risk for substance abuse and pathological gambling disorder. A growing body of evidence suggests that patients with these disorders show abnormality in the power of slow oscillations of resting-state brain activity. It is particularly interesting that previous studies have demonstrated that resting state activities in medial prefrontal cortex (MPFC) are associated with HA or NS scores, although the relation between the power of resting state slow oscillations and these temperament dimensions remains poorly elucidated. This preliminary study investigated the biological bases of these temperament traits by particularly addressing the resting state low-frequency fluctuations in MPFC. Regional hemodynamic changes in channels covering MPFC during 5-min resting states were measured from 22 healthy participants using near-infrared spectroscopy (NIRS). These data were used for correlation analyses. Results show that the power of slow oscillations during resting state around the dorsal part of MPFC is negatively correlated with the HA score. In contrast, NS was positively correlated with the power of resting state slow oscillations around the ventral part of MPFC. These results suggest that the powers of slow oscillation at rest in dorsal or ventral MPFC, respectively, reflect the degrees of HA and NS. This exploratory study therefore uncovers novel neural bases of HA and NS. We discuss a neural mechanism underlying aversion-related and reward-related processing based on results obtained from this study.

Original languageEnglish
Article number115
JournalFrontiers in Systems Neuroscience
Volume7
Issue numberDEC
DOIs
Publication statusPublished - Dec 17 2013
Externally publishedYes

Fingerprint

Near-Infrared Spectroscopy
Prefrontal Cortex
Temperament
Gambling
Major Depressive Disorder
Anxiety Disorders
Reward
Substance-Related Disorders
Healthy Volunteers
Hemodynamics
Equipment and Supplies
Power (Psychology)
Brain

Keywords

  • Aversion
  • Harm avoidance
  • Low-frequency fluctuations
  • Medial prefrontal cortex (MPFC)
  • Novelty seeking
  • Personality
  • Resting state
  • Reward

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Developmental Neuroscience

Cite this

Resting state low-frequency fluctuations in prefrontal cortex reflect degrees of harm avoidance and novelty seeking : An exploratory NIRS study. / Nakao, Takashi; Matsumoto, Tomoya; Shimizu, Daisuke; Morita, Machiko; Yoshimura, Shinpei; Northoff, Georg; Morinobu, Shigeru; Okamoto, Yasumasa; Yamawaki, Shigeto.

In: Frontiers in Systems Neuroscience, Vol. 7, No. DEC, 115, 17.12.2013.

Research output: Contribution to journalArticle

Nakao, Takashi ; Matsumoto, Tomoya ; Shimizu, Daisuke ; Morita, Machiko ; Yoshimura, Shinpei ; Northoff, Georg ; Morinobu, Shigeru ; Okamoto, Yasumasa ; Yamawaki, Shigeto. / Resting state low-frequency fluctuations in prefrontal cortex reflect degrees of harm avoidance and novelty seeking : An exploratory NIRS study. In: Frontiers in Systems Neuroscience. 2013 ; Vol. 7, No. DEC.
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