Respiratory-related arterial pressure variability as an indicator of graded blood loss: Involvement of the autonomic nervous system

Hsien Yong Lai, Cheryl C H Yang, Fan Yen Huang, Yi Lee, Yu Ling Kuo, Terry B J Kuo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

During positive pressure mechanical ventilation, percentile systolic pressure variation (%SPV) or respiratory-related arterial pressure variability (RAPV) have both been used in assessment of graded haemorrhage. We aimed to investigate whether changes in %SPV and RAPV are correlated during graded haemorrhage (by 5, 10 or 20% of the estimated blood volume) in anaesthetized positive pressure ventilated rats and to investigate the involvement of autonomic regulation. Saline vehicle or atropine produced no discernible effect on baseline %SPV or RAPV but, thereafter, %SPV and RAPV increased progressively with graded haemorrhage. Propranolol significantly decreased baseline %SPV and RAPV and changes induced in %SPV and RAPV by graded haemorrhage. Phentolamine significantly enhanced baseline %SPV and RAPV, and further enhancement of %SPV and RAPV by graded haemorrhage did not occur until 20% of the estimated blood volume was removed. RAPV was significantly correlated with %SPV in all experimental groups. We conclude that RAPV is comparable with %SPV as an indicator of graded haemorrhage and that, in anaesthetized and positive pressure ventilated rats, both are dependent on autonomic function, especially β-adrenoceptors.

Original languageEnglish
Pages (from-to)491-497
Number of pages7
JournalClinical Science
Volume105
Issue number4
DOIs
Publication statusPublished - Oct 1 2003
Externally publishedYes

Fingerprint

Autonomic Nervous System
Arterial Pressure
Hemorrhage
Blood Volume
Pressure
Positive-Pressure Respiration
Phentolamine
Atropine
Artificial Respiration
Propranolol
Adrenergic Receptors
Blood Pressure

Keywords

  • Blood volume
  • Frequency domain
  • Power spectral analysis
  • Sympathetic activity
  • Systolic pressure variation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Respiratory-related arterial pressure variability as an indicator of graded blood loss : Involvement of the autonomic nervous system. / Lai, Hsien Yong; Yang, Cheryl C H; Huang, Fan Yen; Lee, Yi; Kuo, Yu Ling; Kuo, Terry B J.

In: Clinical Science, Vol. 105, No. 4, 01.10.2003, p. 491-497.

Research output: Contribution to journalArticle

Lai, Hsien Yong ; Yang, Cheryl C H ; Huang, Fan Yen ; Lee, Yi ; Kuo, Yu Ling ; Kuo, Terry B J. / Respiratory-related arterial pressure variability as an indicator of graded blood loss : Involvement of the autonomic nervous system. In: Clinical Science. 2003 ; Vol. 105, No. 4. pp. 491-497.
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