Resistance of Mycobacterium tuberculosis to Four First-line Anti-tuberculosis Drugs in a Referral Hospital in Northern Taiwan, 2002-2006

林 賢君(Shian-Jiun Lin), 余 芳蘭(Fang-Lan Yu), 李 兆清(Jau-Ching Lee), 白 冠壬(Kuan-Jen Bai), 李 俊年(Chun-Nin Lee), 許 翰琳(Han-Lin Hsu), 余 明治(Ming-Chih Yu)

Research output: Contribution to journalArticle

Abstract

Introduction: The purpose of this retrospective study was to investigate the drug resistance of Mycobacterium tuberculosis to 4 first-line anti-tuberculosis (TB) drugs (isoniazid (INH), rifampin (RIF), ethambutol (EMB), streptomycin (SM)) at Taipei Medical University-Wan Fang Hospital from 2002 to 2006.
Methods: From 1 January 2002 through 31 December 2006, drug susceptibility testing for first-line anti-TB drugs, including INH, RIF, EMB, and SM, was performed using the indirect agar proportion method. A retrospective review of medical records to define the drug resistance of new, previously treated, and combined cases was conducted.
Results: Of the 436 M. tuberculosis isolates, 343 were recovered from new cases and 93 from previously treated cases. The combined drug resistance rate to at least 1 drug was 17.6%. The drug resistance rate to at least 1 drug among new cases was 11.7% and among previously treated cases was 39.8%. The combined drug resistance rate to individual drugs was 12.4% to INH, 7.1% to RIF, 3.2% to EMB, and 9.2% to SM. The rates of combined multidrug resistance (resistance to at least INH and RIF), among new cases, and previously treated cases were 5.7%, 1.5%, and 21.5%, respectively.
Conclusions: Drug resistance remains a serious problem in the treatment of TB in Taiwan. When treating a TB patient, drug resistance should be considered, especially in previously treated cases.
Original languageEnglish
Pages (from-to)316-324
Number of pages9
Journal胸腔醫學
Volume23
Issue number5
Publication statusPublished - 2008

Fingerprint

Taiwan
Mycobacterium tuberculosis
Drug Resistance
Tuberculosis
Referral and Consultation
Rifampin
Ethambutol
Pharmaceutical Preparations
Streptomycin
Isoniazid
Multiple Drug Resistance
Agar
Medical Records
Retrospective Studies

Keywords

  • 抗藥性
  • 結核菌
  • drug resistance
  • Mycobacterium tuberculosis

Cite this

Resistance of Mycobacterium tuberculosis to Four First-line Anti-tuberculosis Drugs in a Referral Hospital in Northern Taiwan, 2002-2006. / 林賢君(Shian-Jiun Lin); 余芳蘭(Fang-Lan Yu); 李兆清(Jau-Ching Lee); 白冠壬(Kuan-Jen Bai); 李俊年(Chun-Nin Lee); 許翰琳(Han-Lin Hsu); 余明治(Ming-Chih Yu).

In: 胸腔醫學, Vol. 23, No. 5, 2008, p. 316-324.

Research output: Contribution to journalArticle

@article{8052d6ea7e5743a89f5781599e135ff9,
title = "Resistance of Mycobacterium tuberculosis to Four First-line Anti-tuberculosis Drugs in a Referral Hospital in Northern Taiwan, 2002-2006",
abstract = "Introduction: The purpose of this retrospective study was to investigate the drug resistance of Mycobacterium tuberculosis to 4 first-line anti-tuberculosis (TB) drugs (isoniazid (INH), rifampin (RIF), ethambutol (EMB), streptomycin (SM)) at Taipei Medical University-Wan Fang Hospital from 2002 to 2006.Methods: From 1 January 2002 through 31 December 2006, drug susceptibility testing for first-line anti-TB drugs, including INH, RIF, EMB, and SM, was performed using the indirect agar proportion method. A retrospective review of medical records to define the drug resistance of new, previously treated, and combined cases was conducted.Results: Of the 436 M. tuberculosis isolates, 343 were recovered from new cases and 93 from previously treated cases. The combined drug resistance rate to at least 1 drug was 17.6{\%}. The drug resistance rate to at least 1 drug among new cases was 11.7{\%} and among previously treated cases was 39.8{\%}. The combined drug resistance rate to individual drugs was 12.4{\%} to INH, 7.1{\%} to RIF, 3.2{\%} to EMB, and 9.2{\%} to SM. The rates of combined multidrug resistance (resistance to at least INH and RIF), among new cases, and previously treated cases were 5.7{\%}, 1.5{\%}, and 21.5{\%}, respectively.Conclusions: Drug resistance remains a serious problem in the treatment of TB in Taiwan. When treating a TB patient, drug resistance should be considered, especially in previously treated cases.",
keywords = "抗藥性, 結核菌, drug resistance, Mycobacterium tuberculosis, 抗藥性, 結核菌, drug resistance, Mycobacterium tuberculosis",
author = "林, {賢君(Shian-Jiun Lin)} and 余, {芳蘭(Fang-Lan Yu)} and 李, {兆清(Jau-Ching Lee)} and 白, {冠壬(Kuan-Jen Bai)} and 李, {俊年(Chun-Nin Lee)} and 許, {翰琳(Han-Lin Hsu)} and 余, {明治(Ming-Chih Yu)}",
year = "2008",
language = "English",
volume = "23",
pages = "316--324",
journal = "胸腔醫學",
issn = "1023-9855",
publisher = "臺灣胸腔暨重症加護醫學會",
number = "5",

}

TY - JOUR

T1 - Resistance of Mycobacterium tuberculosis to Four First-line Anti-tuberculosis Drugs in a Referral Hospital in Northern Taiwan, 2002-2006

AU - 林, 賢君(Shian-Jiun Lin)

AU - 余, 芳蘭(Fang-Lan Yu)

AU - 李, 兆清(Jau-Ching Lee)

AU - 白, 冠壬(Kuan-Jen Bai)

AU - 李, 俊年(Chun-Nin Lee)

AU - 許, 翰琳(Han-Lin Hsu)

AU - 余, 明治(Ming-Chih Yu)

PY - 2008

Y1 - 2008

N2 - Introduction: The purpose of this retrospective study was to investigate the drug resistance of Mycobacterium tuberculosis to 4 first-line anti-tuberculosis (TB) drugs (isoniazid (INH), rifampin (RIF), ethambutol (EMB), streptomycin (SM)) at Taipei Medical University-Wan Fang Hospital from 2002 to 2006.Methods: From 1 January 2002 through 31 December 2006, drug susceptibility testing for first-line anti-TB drugs, including INH, RIF, EMB, and SM, was performed using the indirect agar proportion method. A retrospective review of medical records to define the drug resistance of new, previously treated, and combined cases was conducted.Results: Of the 436 M. tuberculosis isolates, 343 were recovered from new cases and 93 from previously treated cases. The combined drug resistance rate to at least 1 drug was 17.6%. The drug resistance rate to at least 1 drug among new cases was 11.7% and among previously treated cases was 39.8%. The combined drug resistance rate to individual drugs was 12.4% to INH, 7.1% to RIF, 3.2% to EMB, and 9.2% to SM. The rates of combined multidrug resistance (resistance to at least INH and RIF), among new cases, and previously treated cases were 5.7%, 1.5%, and 21.5%, respectively.Conclusions: Drug resistance remains a serious problem in the treatment of TB in Taiwan. When treating a TB patient, drug resistance should be considered, especially in previously treated cases.

AB - Introduction: The purpose of this retrospective study was to investigate the drug resistance of Mycobacterium tuberculosis to 4 first-line anti-tuberculosis (TB) drugs (isoniazid (INH), rifampin (RIF), ethambutol (EMB), streptomycin (SM)) at Taipei Medical University-Wan Fang Hospital from 2002 to 2006.Methods: From 1 January 2002 through 31 December 2006, drug susceptibility testing for first-line anti-TB drugs, including INH, RIF, EMB, and SM, was performed using the indirect agar proportion method. A retrospective review of medical records to define the drug resistance of new, previously treated, and combined cases was conducted.Results: Of the 436 M. tuberculosis isolates, 343 were recovered from new cases and 93 from previously treated cases. The combined drug resistance rate to at least 1 drug was 17.6%. The drug resistance rate to at least 1 drug among new cases was 11.7% and among previously treated cases was 39.8%. The combined drug resistance rate to individual drugs was 12.4% to INH, 7.1% to RIF, 3.2% to EMB, and 9.2% to SM. The rates of combined multidrug resistance (resistance to at least INH and RIF), among new cases, and previously treated cases were 5.7%, 1.5%, and 21.5%, respectively.Conclusions: Drug resistance remains a serious problem in the treatment of TB in Taiwan. When treating a TB patient, drug resistance should be considered, especially in previously treated cases.

KW - 抗藥性

KW - 結核菌

KW - drug resistance

KW - Mycobacterium tuberculosis

KW - 抗藥性

KW - 結核菌

KW - drug resistance

KW - Mycobacterium tuberculosis

M3 - Article

VL - 23

SP - 316

EP - 324

JO - 胸腔醫學

JF - 胸腔醫學

SN - 1023-9855

IS - 5

ER -