Research of StemBios cell therapy on dental implants containing nanostructured surfaces: Biomechanical behaviors, microstructural characteristics, and clinical trial

Keng Liang Ou, Chao Chia Weng, Chi Chang Wu, Yun Ho Lin, Hsi Jen Chiang, Tzu Sen Yang, James Wang, Yun Yen, Han Yi Cheng, Erwan Sugiatno

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Purpose: The aim of the present study was to examine the osseointegration in low-density bone tissue for SLAffinity-treated implants with StemBios (SB) cell therapy. Materials and Methods: The morphologies of SLAffinity-treated surfaces were characterized using scanning electron microscopy. In the animal model, implants were installed in the mandibular canine-premolar area of 12 miniature pigs. Each pig received 3 implants of machine, sand blasted, large grit, and acid etched, and SLAffinity-treated implants. In the clinical trial, 10 patients received 1 SLAffinity-treated implant in the maxilla in the posterior area and 1 patient with low bone tissue density received 2 SLAffinity-treated implants with SB cell therapy. Resonance frequency analysis and computed tomography were assessed monthly over the first 3 months after implant placement. Results: The results demonstrated that surface treatment significantly affected early osseointegration in patients who received SB cell therapy. SB cell therapy transferred the stress caused by the implant more uniformly, and the stress decreased with healing time. SLAffinity-treated implants also proved clinically successful after the 3 months. Conclusion: The SLAffinity treatments enhanced osseointegration significantly, especially at early stages of bone tissue healing with SB cell therapy.

Original languageEnglish
Pages (from-to)63-73
Number of pages11
JournalImplant Dentistry
Volume25
Issue number1
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • bone tissue response
  • early osseointegration
  • nano/microporous surface treatment
  • SB cell therapy

ASJC Scopus subject areas

  • Oral Surgery

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