Research of electrosurgical unit with novel antiadhesion composite thin film for tumor ablation: Microstructural characteristics, thermal conduction properties, and biological behaviors

Yun-Dun Shen, Li Hsiang Lin, Hsi Jen Chiang, Keng Liang Ou, Han Yi Cheng

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The objective of this study was to use surface functionalization to uvaluate the antiadhesion property and thermal injury effects on the liver when using a novel electrosurgical unit with nanostructured-doped diamond-like carbon (DLC-Cu) thin films for tumor ablations. The physical and chemical properties of DLC-Cu thin films were characterized by contact angle goniometer, scanning electron microscope, and transmission electron microscope. Three-dimensional (3D) hepatic models were reconstructed using magnetic resonance imaging to simulate a clinical electrosurgical operation. The results indicated a significant increase of the contact angle on the nanostructured DLC-Cu thin films, and the antiadhesion properties were also observed in an animal model. Furthermore, the surgical temperature in the DLC-Cu electrosurgical unit was found to be significantly lower than the untreated unit when analyzed using 3D models and thermal images. In addition, DLC-Cu electrodes caused a relatively small injury area and lateral thermal effect. The results indicated that the nanostructured DLC-Cu thin film coating reduced excessive thermal injury and tissue adherence effect in the liver.

Original languageEnglish
Pages (from-to)96-105
Number of pages10
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume104
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Composite films
Ablation
Tumors
Thin films
Liver
Thermal effects
Contact angle
Electron microscopes
Goniometers
Diamond
Magnetic resonance
Chemical properties
Diamonds
Animals
Carbon
Physical properties
Tissue
Scanning
Imaging techniques
Coatings

Keywords

  • antiadhesion
  • biomechanics
  • DLC-Cu thin film
  • tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Research of electrosurgical unit with novel antiadhesion composite thin film for tumor ablation : Microstructural characteristics, thermal conduction properties, and biological behaviors. / Shen, Yun-Dun; Lin, Li Hsiang; Chiang, Hsi Jen; Ou, Keng Liang; Cheng, Han Yi.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 104, No. 1, 01.01.2016, p. 96-105.

Research output: Contribution to journalArticle

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