Report of invasive Rhodococcus equi infections in Taiwan, with an emphasis on the emergence of multidrug-resistant strains

Po Ren Hsueh, Chien Ching Hung, Lee Jeng Teng, Ming Chih Yu, Yu Chi Chen, Hua Kung Wang, Kwen Tay Luh

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

From November 1995 to October 1997, seven patients with invasive infections due to Rhodococcus equi were treated in Taiwan. Four patients had pulmonary lesions, and one each of the remaining three patients had a recurrent Port-A-Cath (Kabi-Pharmacia, North Ryde, New South Wales, Australia)- related bacteremia, a primary bacteremia, and a brain abscess. Three patients had underlying hematologic malignancies, and one each of the remaining four patients had diabetes mellitus, Waldenstrom's macroglobulinemia, long-term use of steroids, and AIDS. The 13 isolates of R. equi recovered from these patients were identified by using API Coryne System (bioMerieux, Marcy l'Etoile, France), VITEK GPI card (bioMerieux Vitek, Hazelwood, MO), supplemental biochemical tests, and cellular fatty acid chromatograms. Susceptibilities of these isolates to 16 antimicrobial agents, with use of the agar dilution method, varied; among them, amikacin and trimethoprim-sulfamethoxazole were the most active agents. Different random amplified polymorphic DNA (RAPD) patterns of isolates from different patients documented the lack of epidemiological relatedness of the causative organisms of these infections. This study confirms the emergence of multidrug- resistant R. equi infection in Taiwan and documents the relapsing or reactivating nature of this infection.

Original languageEnglish
Pages (from-to)370-375
Number of pages6
JournalClinical Infectious Diseases
Volume27
Issue number2
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Rhodococcus equi
Taiwan
Infection
Bacteremia
Waldenstrom Macroglobulinemia
Vascular Access Devices
Brain Abscess
South Australia
New South Wales
Amikacin
Sulfamethoxazole Drug Combination Trimethoprim
Hematologic Neoplasms
Anti-Infective Agents
Agar
France
Diabetes Mellitus
Acquired Immunodeficiency Syndrome
Fatty Acids
Steroids
Lung

ASJC Scopus subject areas

  • Immunology

Cite this

Report of invasive Rhodococcus equi infections in Taiwan, with an emphasis on the emergence of multidrug-resistant strains. / Hsueh, Po Ren; Hung, Chien Ching; Teng, Lee Jeng; Yu, Ming Chih; Chen, Yu Chi; Wang, Hua Kung; Luh, Kwen Tay.

In: Clinical Infectious Diseases, Vol. 27, No. 2, 1998, p. 370-375.

Research output: Contribution to journalArticle

Hsueh, Po Ren ; Hung, Chien Ching ; Teng, Lee Jeng ; Yu, Ming Chih ; Chen, Yu Chi ; Wang, Hua Kung ; Luh, Kwen Tay. / Report of invasive Rhodococcus equi infections in Taiwan, with an emphasis on the emergence of multidrug-resistant strains. In: Clinical Infectious Diseases. 1998 ; Vol. 27, No. 2. pp. 370-375.
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