Repeated and multiple new vertebral compression fractures after percutaneous transpedicular vertebroplasty

Yuan Y. Tseng, Tao Chieh Yang, Po Hsun Tu, Yang L. Lo, Shun T. Yang

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

STUDY DESIGN. A retrospective study to detect patients with new-onset compression fractures following vertebroplasty. OBJECTIVE. To investigate the characteristics and associated risk factors of new-onset vertebral compression fractures after vertebroplasty. SUMMARY OF BACKGROUND DATA. Percutaneous vertebroplasty is a well-established technique for treating osteoporotic compression fractures. Short-term results are promising, but longer-term studies have suggested a possible accelerated failure rate in the adjacent vertebral body. METHODS. We retrospectively reviewed patients with osteoporotic compression fractures from January 2000 to June 2006. The patients received percutaneous vertebroplasty with bone cement augmentation. Long-term follow-up radiographically identified the occurrence of vertebral fracture (minimum follow-up 24 months) after an initial vertebral fracture. RESULTS. In 852 patients (1131 vertebrae), 58.8% to 63.8% of new compression fractures after vertebroplasty were adjacent compression fractures. Adjacent fractures occurred much sooner than nonadjacent fractures; (71.9 ± 71.8 days vs. 286.8 ± 232.8 days, P <0.001). In patients who experienced vertebral compression fractures 2 or more times, older age, lower baseline bone mineral density (BMD), and more pre-existing vertebral compression fractures were demonstrated in this study (P <0.005). The gender and amount of cemented polymethyl methacrylate were not statistically different between Groups A (1 vertebral compression fracture) and B (vertebral compression fracture ≥2 times). CONCLUSION. New-onset vertebral compression fractures occurred repeatedly within a few years after vertebroplasty. New-onset adjacent-level fractures occurred sooner and were more predominate than nonadjacent level fractures. The results of this study suggest that older patient age, lower baseline BMD, and more pre-existing vertebral fractures were found to be risk factors for multiple vertebral compression fractures.

Original languageEnglish
Pages (from-to)1917-1922
Number of pages6
JournalSpine
Volume34
Issue number18
DOIs
Publication statusPublished - Aug 2009

Fingerprint

Vertebroplasty
Compression Fractures
Osteoporotic Fractures
Bone Density
Bone Cements
Polymethyl Methacrylate

Keywords

  • Adjacent fracture
  • Bone mineral density
  • Compression fracture
  • Osteoporosis
  • Vertebroplasty

ASJC Scopus subject areas

  • Clinical Neurology
  • Orthopedics and Sports Medicine

Cite this

Repeated and multiple new vertebral compression fractures after percutaneous transpedicular vertebroplasty. / Tseng, Yuan Y.; Yang, Tao Chieh; Tu, Po Hsun; Lo, Yang L.; Yang, Shun T.

In: Spine, Vol. 34, No. 18, 08.2009, p. 1917-1922.

Research output: Contribution to journalArticle

Tseng, Yuan Y. ; Yang, Tao Chieh ; Tu, Po Hsun ; Lo, Yang L. ; Yang, Shun T. / Repeated and multiple new vertebral compression fractures after percutaneous transpedicular vertebroplasty. In: Spine. 2009 ; Vol. 34, No. 18. pp. 1917-1922.
@article{0c56527e8ef04174a8dc93eb7bbf2f3e,
title = "Repeated and multiple new vertebral compression fractures after percutaneous transpedicular vertebroplasty",
abstract = "STUDY DESIGN. A retrospective study to detect patients with new-onset compression fractures following vertebroplasty. OBJECTIVE. To investigate the characteristics and associated risk factors of new-onset vertebral compression fractures after vertebroplasty. SUMMARY OF BACKGROUND DATA. Percutaneous vertebroplasty is a well-established technique for treating osteoporotic compression fractures. Short-term results are promising, but longer-term studies have suggested a possible accelerated failure rate in the adjacent vertebral body. METHODS. We retrospectively reviewed patients with osteoporotic compression fractures from January 2000 to June 2006. The patients received percutaneous vertebroplasty with bone cement augmentation. Long-term follow-up radiographically identified the occurrence of vertebral fracture (minimum follow-up 24 months) after an initial vertebral fracture. RESULTS. In 852 patients (1131 vertebrae), 58.8{\%} to 63.8{\%} of new compression fractures after vertebroplasty were adjacent compression fractures. Adjacent fractures occurred much sooner than nonadjacent fractures; (71.9 ± 71.8 days vs. 286.8 ± 232.8 days, P <0.001). In patients who experienced vertebral compression fractures 2 or more times, older age, lower baseline bone mineral density (BMD), and more pre-existing vertebral compression fractures were demonstrated in this study (P <0.005). The gender and amount of cemented polymethyl methacrylate were not statistically different between Groups A (1 vertebral compression fracture) and B (vertebral compression fracture ≥2 times). CONCLUSION. New-onset vertebral compression fractures occurred repeatedly within a few years after vertebroplasty. New-onset adjacent-level fractures occurred sooner and were more predominate than nonadjacent level fractures. The results of this study suggest that older patient age, lower baseline BMD, and more pre-existing vertebral fractures were found to be risk factors for multiple vertebral compression fractures.",
keywords = "Adjacent fracture, Bone mineral density, Compression fracture, Osteoporosis, Vertebroplasty",
author = "Tseng, {Yuan Y.} and Yang, {Tao Chieh} and Tu, {Po Hsun} and Lo, {Yang L.} and Yang, {Shun T.}",
year = "2009",
month = "8",
doi = "10.1097/BRS.0b013e3181ac8f07",
language = "English",
volume = "34",
pages = "1917--1922",
journal = "Spine",
issn = "1528-1159",
publisher = "Lippincott Williams and Wilkins",
number = "18",

}

TY - JOUR

T1 - Repeated and multiple new vertebral compression fractures after percutaneous transpedicular vertebroplasty

AU - Tseng, Yuan Y.

AU - Yang, Tao Chieh

AU - Tu, Po Hsun

AU - Lo, Yang L.

AU - Yang, Shun T.

PY - 2009/8

Y1 - 2009/8

N2 - STUDY DESIGN. A retrospective study to detect patients with new-onset compression fractures following vertebroplasty. OBJECTIVE. To investigate the characteristics and associated risk factors of new-onset vertebral compression fractures after vertebroplasty. SUMMARY OF BACKGROUND DATA. Percutaneous vertebroplasty is a well-established technique for treating osteoporotic compression fractures. Short-term results are promising, but longer-term studies have suggested a possible accelerated failure rate in the adjacent vertebral body. METHODS. We retrospectively reviewed patients with osteoporotic compression fractures from January 2000 to June 2006. The patients received percutaneous vertebroplasty with bone cement augmentation. Long-term follow-up radiographically identified the occurrence of vertebral fracture (minimum follow-up 24 months) after an initial vertebral fracture. RESULTS. In 852 patients (1131 vertebrae), 58.8% to 63.8% of new compression fractures after vertebroplasty were adjacent compression fractures. Adjacent fractures occurred much sooner than nonadjacent fractures; (71.9 ± 71.8 days vs. 286.8 ± 232.8 days, P <0.001). In patients who experienced vertebral compression fractures 2 or more times, older age, lower baseline bone mineral density (BMD), and more pre-existing vertebral compression fractures were demonstrated in this study (P <0.005). The gender and amount of cemented polymethyl methacrylate were not statistically different between Groups A (1 vertebral compression fracture) and B (vertebral compression fracture ≥2 times). CONCLUSION. New-onset vertebral compression fractures occurred repeatedly within a few years after vertebroplasty. New-onset adjacent-level fractures occurred sooner and were more predominate than nonadjacent level fractures. The results of this study suggest that older patient age, lower baseline BMD, and more pre-existing vertebral fractures were found to be risk factors for multiple vertebral compression fractures.

AB - STUDY DESIGN. A retrospective study to detect patients with new-onset compression fractures following vertebroplasty. OBJECTIVE. To investigate the characteristics and associated risk factors of new-onset vertebral compression fractures after vertebroplasty. SUMMARY OF BACKGROUND DATA. Percutaneous vertebroplasty is a well-established technique for treating osteoporotic compression fractures. Short-term results are promising, but longer-term studies have suggested a possible accelerated failure rate in the adjacent vertebral body. METHODS. We retrospectively reviewed patients with osteoporotic compression fractures from January 2000 to June 2006. The patients received percutaneous vertebroplasty with bone cement augmentation. Long-term follow-up radiographically identified the occurrence of vertebral fracture (minimum follow-up 24 months) after an initial vertebral fracture. RESULTS. In 852 patients (1131 vertebrae), 58.8% to 63.8% of new compression fractures after vertebroplasty were adjacent compression fractures. Adjacent fractures occurred much sooner than nonadjacent fractures; (71.9 ± 71.8 days vs. 286.8 ± 232.8 days, P <0.001). In patients who experienced vertebral compression fractures 2 or more times, older age, lower baseline bone mineral density (BMD), and more pre-existing vertebral compression fractures were demonstrated in this study (P <0.005). The gender and amount of cemented polymethyl methacrylate were not statistically different between Groups A (1 vertebral compression fracture) and B (vertebral compression fracture ≥2 times). CONCLUSION. New-onset vertebral compression fractures occurred repeatedly within a few years after vertebroplasty. New-onset adjacent-level fractures occurred sooner and were more predominate than nonadjacent level fractures. The results of this study suggest that older patient age, lower baseline BMD, and more pre-existing vertebral fractures were found to be risk factors for multiple vertebral compression fractures.

KW - Adjacent fracture

KW - Bone mineral density

KW - Compression fracture

KW - Osteoporosis

KW - Vertebroplasty

UR - http://www.scopus.com/inward/record.url?scp=69749085404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69749085404&partnerID=8YFLogxK

U2 - 10.1097/BRS.0b013e3181ac8f07

DO - 10.1097/BRS.0b013e3181ac8f07

M3 - Article

C2 - 19652633

AN - SCOPUS:69749085404

VL - 34

SP - 1917

EP - 1922

JO - Spine

JF - Spine

SN - 1528-1159

IS - 18

ER -