Renoprotective effects of soy protein hydrolysates in Nw-nitro-L-arginine methyl e ster hydrochloride-induced hypertensive rats

Hsin Yi Yang, Jiun-Rong Chen

Research output: Contribution to journalArticle

Abstract

Pepsin-digested soy protein hydrolysate (SPH) has been reported to be responsible for many of the physiological benefits associated with soy protein consumption. In the present study, we investigated the effects of SPH with angiotensin-converting enzyme (ACE) inhibitory potential on blood pressure and renal injuries in rats with Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertension. Rats were fed a diet containing L-NAME (50 mg/kg body weight) with or without SPH (at 1%, 3%, or 5%) for 6 weeks. We found that ingestion of SPH ameliorated the development of hypertension during the 6-week experimental period. SPH was also found to ameliorate renal function by decreasing urinary protein excretion and elevating the creatinine clearance rate. The levels of kidney ACE activity, malonaldehyde, tumor necrosis factor-α and plasminogen activator inhibitor-1, and the expression of CYP4A decreased in the 5% SPH group. Consumption of 5% SPH also ameliorated renal damage according to the histopathological analysis. These findings suggest that SPH might ameliorate the elevation of blood pressure and show renoprotective effects in nitric oxide (NO)-deficient rats, and one possible mechanism might be mediation via its ACE inhibitory activity.

Original languageEnglish
Pages (from-to)1477-1483
Number of pages7
JournalHypertension Research
Volume31
Issue number7
DOIs
Publication statusPublished - 2008

Fingerprint

Protein Hydrolysates
Soybean Proteins
Arginine
Peptidyl-Dipeptidase A
Kidney
NG-Nitroarginine Methyl Ester
Cytochrome P-450 CYP4A
Blood Pressure
Hypertension
Pepsin A
Plasminogen Activator Inhibitor 1
Malondialdehyde
Creatinine
Nitric Oxide
Tumor Necrosis Factor-alpha
Eating
Body Weight
Diet

Keywords

  • Angiotensin-converting enzyme
  • Kidney
  • Soy protein

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Renoprotective effects of soy protein hydrolysates in Nw-nitro-L-arginine methyl e ster hydrochloride-induced hypertensive rats. / Yang, Hsin Yi; Chen, Jiun-Rong.

In: Hypertension Research, Vol. 31, No. 7, 2008, p. 1477-1483.

Research output: Contribution to journalArticle

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