Renal insufficiency plays a crucial association factor in severe knee osteoarthritis-induced pain in patients with total knee replacement: A retrospective study

Chung Ching Chio, Man Kit Siu, Yu Ting Tai, Tyng Guey Chen, Wei Pin Ho, Jui Tai Chen, Hsiao Chien Tsai, Ruei Ming Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Pain, the main symptom of osteoarthritis (OA), can lead to functional disability in patients with knee OA. Understanding the association factors related to knee pain is important since preventing OA-induced disabilities can be achieved by modifying these pain-associated issues. Therefore, this study was aimed to investigate the association factors for OA-induced knee pain in Taiwanese patients who received total knee replacements (TKR).In this retrospective study, 357 subjects who had undergone TKR at the Taipei Municipal Wan-Fang Hospital were recruited. The distribution of pain severity among patients with knee OA was evaluated. Demographic data and clinical parameters were analyzed to determine relationships between these variables and the severity of knee OA pain.Of the 357 patients studied, 54% and 33% had moderate and severe knee pain, respectively. Furthermore, a multivariate logistic regression analysis revealed that serum creatinine (>1.5mg/dL) and an estimated glomerular filtration rate (EGFR) (<60mL/min/1.73 m2) were significantly associated with severe knee pain in OA patients. A significant correlation between severe knee pain and serum creatinine or EGFR was demonstrated by Pearson correlations.Taken together, the renal insufficiency defined by an elevated serum creatinine or a low EGFR in OA patients who required TKR was associated with severe knee pain. These variables must be considered while treating knee OA pain, especially in those patients with severe pain.

Original languageEnglish
Article numbere19125
JournalMedicine (United States)
Volume99
Issue number6
DOIs
Publication statusPublished - Jan 1 2020

Keywords

  • estimated glomerular filtration rate
  • osteoarthritis
  • renal insufficiency
  • serum creatinine
  • severe knee pain
  • Arthroplasty, Replacement, Knee/adverse effects
  • Glomerular Filtration Rate
  • Humans
  • Male
  • Creatinine/blood
  • Osteoarthritis, Knee/complications
  • Renal Insufficiency/complications
  • Arthralgia/etiology
  • Female
  • Aged
  • Retrospective Studies
  • Pain Measurement

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Renal insufficiency plays a crucial association factor in severe knee osteoarthritis-induced pain in patients with total knee replacement: A retrospective study'. Together they form a unique fingerprint.

Cite this