Renal expression of hypoxia inducible factor-1α in patients with chronic kidney disease

A clinicopathologic study from nephrectomized kidneys

Tung Wei Hunga, Jia Hung Lioua, Kun Tu Yeh, Jen Pi Tsai, Sheng Wen Wu, Hui Chun Tai, Wei Tse Kao, Shu Hui Lin, Ya Wen Cheng, Horng Rong Chang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background & objectives: Hypoxia inducible factor-1α (HIF-1α) has been shown to play a role in the pathogenesis of renal interstitial fibrosis. However, the relationship of HIF-1α expression intensity in human renal tissue with the degree of renal function or renal fibrosis has not been investigated. We therefore, undertook this study to assess the relationship between HIF-1α expression and degree of renal impairment and renal fibrosis using renal tissue from nephrectomized kidneys from patients with chronic kidney disease. Methods: This retrospective study was performed with 70 patients undergoing unilateral or bilateral nephrectomy because of renal cell carcinoma, urothelial cell carcinoma, or renal abscess. Immunohistochemical analysis of HIF-1α expression in non-tumourous or non-abscess renal parenchyma was performed. The patients were divided into two groups: group 1 (n=37) with low intensity HIF-1α expression and group 2 (n=33) with high intensity HIF-1α expression. Results: The intensity of renal HIF-1α expression was significantly associated with serum creatinine level (P=0.005), estimated glomerular filtration rate (P=0.02), fibrosis score of the interstitium (P=0.004) and glomerular sclerosis (P=0.013). A high intensity of HIF-1α expression tended to be associated with lower serum creatinine, higher estimated glomerular filtration rate, low interstitial fibrosis score and low glomerular sclerosis. In addition, multivariate analysis by step-wise logistic regression demonstrated that interstitial fibrosis was the only independent factor associated with the intensity of renal HIF-1α expression (OR 4.107, CI 1.535-11.313, P=0.005). Interpretation & conclusions: This study demonstrated a correlation between intensity of HIF-1α expression and degree of renal interstitial fibrosis. The association demonstrated an elevated HIF-1α expression in less severe kidney disease. The intensity of HIF-1α renal expression plays a role in the pathogenesis of chronic kidney disease.

Original languageEnglish
Pages (from-to)102-110
Number of pages9
JournalIndian Journal of Medical Research
Volume137
Issue number1
Publication statusPublished - Jan 2013
Externally publishedYes

Fingerprint

Hypoxia-Inducible Factor 1
Chronic Renal Insufficiency
Kidney
Fibrosis
Sclerosis
Glomerular Filtration Rate
Renal Cell Carcinoma
Creatinine
Cells
Tissue
Kidney Diseases
Nephrectomy
Serum
Logistics
Abscess

Keywords

  • Chronic kidney disease
  • GFR
  • Hypoxia inducible factor-1α
  • Nephrectomy
  • Renal fibrosis
  • Renal function

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Hunga, T. W., Lioua, J. H., Yeh, K. T., Tsai, J. P., Wu, S. W., Tai, H. C., ... Chang, H. R. (2013). Renal expression of hypoxia inducible factor-1α in patients with chronic kidney disease: A clinicopathologic study from nephrectomized kidneys. Indian Journal of Medical Research, 137(1), 102-110.

Renal expression of hypoxia inducible factor-1α in patients with chronic kidney disease : A clinicopathologic study from nephrectomized kidneys. / Hunga, Tung Wei; Lioua, Jia Hung; Yeh, Kun Tu; Tsai, Jen Pi; Wu, Sheng Wen; Tai, Hui Chun; Kao, Wei Tse; Lin, Shu Hui; Cheng, Ya Wen; Chang, Horng Rong.

In: Indian Journal of Medical Research, Vol. 137, No. 1, 01.2013, p. 102-110.

Research output: Contribution to journalArticle

Hunga, TW, Lioua, JH, Yeh, KT, Tsai, JP, Wu, SW, Tai, HC, Kao, WT, Lin, SH, Cheng, YW & Chang, HR 2013, 'Renal expression of hypoxia inducible factor-1α in patients with chronic kidney disease: A clinicopathologic study from nephrectomized kidneys', Indian Journal of Medical Research, vol. 137, no. 1, pp. 102-110.
Hunga, Tung Wei ; Lioua, Jia Hung ; Yeh, Kun Tu ; Tsai, Jen Pi ; Wu, Sheng Wen ; Tai, Hui Chun ; Kao, Wei Tse ; Lin, Shu Hui ; Cheng, Ya Wen ; Chang, Horng Rong. / Renal expression of hypoxia inducible factor-1α in patients with chronic kidney disease : A clinicopathologic study from nephrectomized kidneys. In: Indian Journal of Medical Research. 2013 ; Vol. 137, No. 1. pp. 102-110.
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abstract = "Background & objectives: Hypoxia inducible factor-1α (HIF-1α) has been shown to play a role in the pathogenesis of renal interstitial fibrosis. However, the relationship of HIF-1α expression intensity in human renal tissue with the degree of renal function or renal fibrosis has not been investigated. We therefore, undertook this study to assess the relationship between HIF-1α expression and degree of renal impairment and renal fibrosis using renal tissue from nephrectomized kidneys from patients with chronic kidney disease. Methods: This retrospective study was performed with 70 patients undergoing unilateral or bilateral nephrectomy because of renal cell carcinoma, urothelial cell carcinoma, or renal abscess. Immunohistochemical analysis of HIF-1α expression in non-tumourous or non-abscess renal parenchyma was performed. The patients were divided into two groups: group 1 (n=37) with low intensity HIF-1α expression and group 2 (n=33) with high intensity HIF-1α expression. Results: The intensity of renal HIF-1α expression was significantly associated with serum creatinine level (P=0.005), estimated glomerular filtration rate (P=0.02), fibrosis score of the interstitium (P=0.004) and glomerular sclerosis (P=0.013). A high intensity of HIF-1α expression tended to be associated with lower serum creatinine, higher estimated glomerular filtration rate, low interstitial fibrosis score and low glomerular sclerosis. In addition, multivariate analysis by step-wise logistic regression demonstrated that interstitial fibrosis was the only independent factor associated with the intensity of renal HIF-1α expression (OR 4.107, CI 1.535-11.313, P=0.005). Interpretation & conclusions: This study demonstrated a correlation between intensity of HIF-1α expression and degree of renal interstitial fibrosis. The association demonstrated an elevated HIF-1α expression in less severe kidney disease. The intensity of HIF-1α renal expression plays a role in the pathogenesis of chronic kidney disease.",
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AU - Tsai, Jen Pi

AU - Wu, Sheng Wen

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AB - Background & objectives: Hypoxia inducible factor-1α (HIF-1α) has been shown to play a role in the pathogenesis of renal interstitial fibrosis. However, the relationship of HIF-1α expression intensity in human renal tissue with the degree of renal function or renal fibrosis has not been investigated. We therefore, undertook this study to assess the relationship between HIF-1α expression and degree of renal impairment and renal fibrosis using renal tissue from nephrectomized kidneys from patients with chronic kidney disease. Methods: This retrospective study was performed with 70 patients undergoing unilateral or bilateral nephrectomy because of renal cell carcinoma, urothelial cell carcinoma, or renal abscess. Immunohistochemical analysis of HIF-1α expression in non-tumourous or non-abscess renal parenchyma was performed. The patients were divided into two groups: group 1 (n=37) with low intensity HIF-1α expression and group 2 (n=33) with high intensity HIF-1α expression. Results: The intensity of renal HIF-1α expression was significantly associated with serum creatinine level (P=0.005), estimated glomerular filtration rate (P=0.02), fibrosis score of the interstitium (P=0.004) and glomerular sclerosis (P=0.013). A high intensity of HIF-1α expression tended to be associated with lower serum creatinine, higher estimated glomerular filtration rate, low interstitial fibrosis score and low glomerular sclerosis. In addition, multivariate analysis by step-wise logistic regression demonstrated that interstitial fibrosis was the only independent factor associated with the intensity of renal HIF-1α expression (OR 4.107, CI 1.535-11.313, P=0.005). Interpretation & conclusions: This study demonstrated a correlation between intensity of HIF-1α expression and degree of renal interstitial fibrosis. The association demonstrated an elevated HIF-1α expression in less severe kidney disease. The intensity of HIF-1α renal expression plays a role in the pathogenesis of chronic kidney disease.

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KW - Nephrectomy

KW - Renal fibrosis

KW - Renal function

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