Renal dysfunction by BK virus infection is correlated with activated T cell level in renal transplantation

Ming Che Lee, Ming Chi Lu, Ning Sheng Lai, Su Chin Liu, Hui Chun Yu, Teng Yi Lin, Shueh Ping Hung, Hsien Bin Huang, Wen Yao Yin

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: BK virus (BKV) is known to be associated with nephropathy. Here, we investigated the relationships between BKV levels, T-cell activation, and kidney function in kidney transplant recipients. Materials and methods: In renal transplant patients and controls, urine BKV levels were detected by quantitative real-time PCR, and the percentage of activated T lymphocytes in blood was determined by flow cytometry. The correlations between viral load, activated T cell percentage, and renal function were determined. Results: Urine BKV viral loads and the activated T cell percentage were significantly elevated in transplant recipients. Correlational analysis indicated that transplant recipients that had BKV levels of more than 106 copies/mL and an activated T lymphocyte percentage of less than 20% were likely to have poor renal function. Conclusions: Urine BKV levels and the percentage of activated T lymphocytes can be used as clinical indices to optimize the dosage of immunosuppressive drugs.

Original languageEnglish
Pages (from-to)330-336
Number of pages7
JournalJournal of Surgical Research
Volume180
Issue number2
DOIs
Publication statusPublished - Apr 2013
Externally publishedYes

Keywords

  • Activated T cell
  • BK virus
  • Immunosuppression
  • Renal dysfunction

ASJC Scopus subject areas

  • Surgery

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