Renal dysfunction after heart transplantation

Incidence, prognosis and risk factors

Ron B. Hsu, Robert J. Chen, Cheng Hsin Lin, Nai Kuan Chou, Wen J. Ko, Shoei Shen Wang, Shu Hsun Chu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background and Purpose: Despite more than 20 years of experience in heart transplantation, the risk factors for development of chronic renal insufficiency in recipients are not well established. This study assessed the incidence, prognosis and risk factors for renal dysfunction after heart transplantation. Methods: We conducted a retrospective analysis of all adult patients (n = 132) who survived for more than 1 year after heart transplantation at our institutions from March 1992 through November 2002. Renal dysfunction was defined as serum creatinine of ≥ 2.0 mg/dL. The incidence and prognosis of renal dysfunction after heart transplantation was estimated by the Kaplan-Meier method and compared by log rank test. Risk factors for renal dysfunction at 1 year after transplantation were evaluated using a logistic regression model. Results: Renal dysfunction was present in 9 patients (7%) before heart transplantation. The cumulative incidence of renal dysfunction after heart transplantation was 23.0 ± 3.8%, 36.1 ± 4.3%, 53.9 ± 4.9%, and 57.3 ± 5.8% at 6 months, 1 year, 5 years and 10 years, respectively, after transplantation. The actuarial survival rate in patients without renal dysfunction at 1 year after transplantation was better than for patients with renal dysfunction at 1 year after transplantation (p = 0.046 by log-rank test). Independent risk factors for renal dysfunction at 1 year after transplantation were age at transplantation (odds ratio, 1.07; p = 0.02), pretransplant serum blood urea nitrogen (odds ratio, 1.07; p = 0.048), and serum creatinine at 6 months after transplantation (odds ratio, 17.0; p <0.001). Conclusions: There was a high incidence of renal dysfunction after heart transplantation. Patients with renal dysfunction had poor long-term prognosis. Serum creatinine at 6 months after transplantation was the most significant major risk factor, followed by age at transplantation and pretransplant blood urea nitrogen.

Original languageEnglish
Pages (from-to)482-486
Number of pages5
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume104
Issue number7
Publication statusPublished - Jul 2005
Externally publishedYes

Fingerprint

Heart Transplantation
Kidney
Transplantation
Incidence
Creatinine
Blood Urea Nitrogen
Odds Ratio
Serum
Logistic Models
Chronic Renal Insufficiency
Cohort Studies
Survival Rate

Keywords

  • Heart transplantation
  • Incidence
  • Kidney failure
  • Risk factors

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Renal dysfunction after heart transplantation : Incidence, prognosis and risk factors. / Hsu, Ron B.; Chen, Robert J.; Lin, Cheng Hsin; Chou, Nai Kuan; Ko, Wen J.; Wang, Shoei Shen; Chu, Shu Hsun.

In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 104, No. 7, 07.2005, p. 482-486.

Research output: Contribution to journalArticle

Hsu, Ron B. ; Chen, Robert J. ; Lin, Cheng Hsin ; Chou, Nai Kuan ; Ko, Wen J. ; Wang, Shoei Shen ; Chu, Shu Hsun. / Renal dysfunction after heart transplantation : Incidence, prognosis and risk factors. In: Journal of the Formosan Medical Association = Taiwan yi zhi. 2005 ; Vol. 104, No. 7. pp. 482-486.
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abstract = "Background and Purpose: Despite more than 20 years of experience in heart transplantation, the risk factors for development of chronic renal insufficiency in recipients are not well established. This study assessed the incidence, prognosis and risk factors for renal dysfunction after heart transplantation. Methods: We conducted a retrospective analysis of all adult patients (n = 132) who survived for more than 1 year after heart transplantation at our institutions from March 1992 through November 2002. Renal dysfunction was defined as serum creatinine of ≥ 2.0 mg/dL. The incidence and prognosis of renal dysfunction after heart transplantation was estimated by the Kaplan-Meier method and compared by log rank test. Risk factors for renal dysfunction at 1 year after transplantation were evaluated using a logistic regression model. Results: Renal dysfunction was present in 9 patients (7{\%}) before heart transplantation. The cumulative incidence of renal dysfunction after heart transplantation was 23.0 ± 3.8{\%}, 36.1 ± 4.3{\%}, 53.9 ± 4.9{\%}, and 57.3 ± 5.8{\%} at 6 months, 1 year, 5 years and 10 years, respectively, after transplantation. The actuarial survival rate in patients without renal dysfunction at 1 year after transplantation was better than for patients with renal dysfunction at 1 year after transplantation (p = 0.046 by log-rank test). Independent risk factors for renal dysfunction at 1 year after transplantation were age at transplantation (odds ratio, 1.07; p = 0.02), pretransplant serum blood urea nitrogen (odds ratio, 1.07; p = 0.048), and serum creatinine at 6 months after transplantation (odds ratio, 17.0; p <0.001). Conclusions: There was a high incidence of renal dysfunction after heart transplantation. Patients with renal dysfunction had poor long-term prognosis. Serum creatinine at 6 months after transplantation was the most significant major risk factor, followed by age at transplantation and pretransplant blood urea nitrogen.",
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T1 - Renal dysfunction after heart transplantation

T2 - Incidence, prognosis and risk factors

AU - Hsu, Ron B.

AU - Chen, Robert J.

AU - Lin, Cheng Hsin

AU - Chou, Nai Kuan

AU - Ko, Wen J.

AU - Wang, Shoei Shen

AU - Chu, Shu Hsun

PY - 2005/7

Y1 - 2005/7

N2 - Background and Purpose: Despite more than 20 years of experience in heart transplantation, the risk factors for development of chronic renal insufficiency in recipients are not well established. This study assessed the incidence, prognosis and risk factors for renal dysfunction after heart transplantation. Methods: We conducted a retrospective analysis of all adult patients (n = 132) who survived for more than 1 year after heart transplantation at our institutions from March 1992 through November 2002. Renal dysfunction was defined as serum creatinine of ≥ 2.0 mg/dL. The incidence and prognosis of renal dysfunction after heart transplantation was estimated by the Kaplan-Meier method and compared by log rank test. Risk factors for renal dysfunction at 1 year after transplantation were evaluated using a logistic regression model. Results: Renal dysfunction was present in 9 patients (7%) before heart transplantation. The cumulative incidence of renal dysfunction after heart transplantation was 23.0 ± 3.8%, 36.1 ± 4.3%, 53.9 ± 4.9%, and 57.3 ± 5.8% at 6 months, 1 year, 5 years and 10 years, respectively, after transplantation. The actuarial survival rate in patients without renal dysfunction at 1 year after transplantation was better than for patients with renal dysfunction at 1 year after transplantation (p = 0.046 by log-rank test). Independent risk factors for renal dysfunction at 1 year after transplantation were age at transplantation (odds ratio, 1.07; p = 0.02), pretransplant serum blood urea nitrogen (odds ratio, 1.07; p = 0.048), and serum creatinine at 6 months after transplantation (odds ratio, 17.0; p <0.001). Conclusions: There was a high incidence of renal dysfunction after heart transplantation. Patients with renal dysfunction had poor long-term prognosis. Serum creatinine at 6 months after transplantation was the most significant major risk factor, followed by age at transplantation and pretransplant blood urea nitrogen.

AB - Background and Purpose: Despite more than 20 years of experience in heart transplantation, the risk factors for development of chronic renal insufficiency in recipients are not well established. This study assessed the incidence, prognosis and risk factors for renal dysfunction after heart transplantation. Methods: We conducted a retrospective analysis of all adult patients (n = 132) who survived for more than 1 year after heart transplantation at our institutions from March 1992 through November 2002. Renal dysfunction was defined as serum creatinine of ≥ 2.0 mg/dL. The incidence and prognosis of renal dysfunction after heart transplantation was estimated by the Kaplan-Meier method and compared by log rank test. Risk factors for renal dysfunction at 1 year after transplantation were evaluated using a logistic regression model. Results: Renal dysfunction was present in 9 patients (7%) before heart transplantation. The cumulative incidence of renal dysfunction after heart transplantation was 23.0 ± 3.8%, 36.1 ± 4.3%, 53.9 ± 4.9%, and 57.3 ± 5.8% at 6 months, 1 year, 5 years and 10 years, respectively, after transplantation. The actuarial survival rate in patients without renal dysfunction at 1 year after transplantation was better than for patients with renal dysfunction at 1 year after transplantation (p = 0.046 by log-rank test). Independent risk factors for renal dysfunction at 1 year after transplantation were age at transplantation (odds ratio, 1.07; p = 0.02), pretransplant serum blood urea nitrogen (odds ratio, 1.07; p = 0.048), and serum creatinine at 6 months after transplantation (odds ratio, 17.0; p <0.001). Conclusions: There was a high incidence of renal dysfunction after heart transplantation. Patients with renal dysfunction had poor long-term prognosis. Serum creatinine at 6 months after transplantation was the most significant major risk factor, followed by age at transplantation and pretransplant blood urea nitrogen.

KW - Heart transplantation

KW - Incidence

KW - Kidney failure

KW - Risk factors

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VL - 104

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EP - 486

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

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