Renal denervation prevents and reverses hyperinsulinemia-induced hypertension in rats

Wann Chu Huang, Te Chao Fang, Juei Tang Cheng

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

Experiments were performed to evaluate the role of the renal nerves in hyperinsulinemia-induced hypertension. Male Sprague-Dawley rats were made hyperinsulinemic by insulin infusion via osmotic minipumps implanted subcutaneously (3.0 mU/kg per minute for 6 weeks). Rats with vehicle infusion served as controls. Bilateral renal denervation was performed either at the beginning of or 4 weeks after insulin infusion. The systolic blood pressure was measured by the tail-cuff method twice a week. Food and water intake and urine flow were measured daily. The results showed that sustained insulin infusion significantly increased plasma insulin concentrations from 277.7±25.8 pmol/L to 609.9±22.2 and 696.7±23.0 pmol/L by the end of weeks 4 and 6, respectively (P

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalHypertension
Volume32
Issue number2
Publication statusPublished - Aug 1998
Externally publishedYes

Keywords

  • Denervated natriuresis
  • Hyperinsulinemia
  • Insulin resistance
  • Renal denervation
  • Renal nerve

ASJC Scopus subject areas

  • Internal Medicine

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