Release of the p53-induced repression on thymidine kinase promoter by single p53-binding sequence

Jean Nian Yuan, Biing Hui Liu, Heng Lee, Yueh Tsern Shaw, Shean Tai Chiou, Wen Chang Chang, Ming Derg Lai

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Herpes simplex thymidine kinase (TK) promoter was shown to be repressed by the wild-type p53. Using a model system that the p53-binding site was linked to the thymidine kinase promoter, we demonstrated that single p53-specific binding site was sufficient to abolish the repression. On the contrary, the mutant p53 had the opposite effects on the HSV-TK promoter in BHK cells. The results suggest that the p53-binding site may act as an enhancer to regulate the gene expression in a novel way in vivo.

Original languageEnglish
Pages (from-to)662-668
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume191
Issue number2
DOIs
Publication statusPublished - Mar 15 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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